73 レチナールアナログを用いるロドプシン再生酵素の構造と機能の解明

概要

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Retinochrome is a photosensitive chromoprotein found in the visual cells of cephalopods. The purposes of this study are elucidation of the chemical circumstances around the chromophore and the stereospecific transformation of all-trans retinal to 11-cis retinal. The results and the conclusion are: (1) Several artificial retinochromes with retinal analogs were newly synthesized. (2) All-trans retinal analogs were stereospecifically photoconverted into 11-cis analogs with catalytic amount of retinochromes. (3) The synthesized retinochromes always showed smaller protein shifts than the natural retinochrome. The difference was accounted for in terms of hydrophobic binding. (4) Reconstituted retinochromes represent the chemical structures of the retinal moiety and their properties are similar to those of bacteriorhodopsin in the ground state and to rhodopsin in the excited state, respectively.
天然有機化合物討論会の論文
1985-09-07