32 Homo-farnesyl-およびhomogeranyl pyrophosphateの酵素的生成 : Prenyltransferaseの基質特異性

概要

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In the study of the substrate specificity of prenyltransferase which catalyzes "Head to Tail" condensation of C_5-unit in the isoprenoid biosynthesis, it was found that C_6- and C_7-compounds, trans-3-methyl-2-pentenyl pyrophosphate (1b) and trans-3-methyl-2-hexenyl pyrophosphate (1c) were reactive with isopentenyl pyrophosphate in the presence of farnesyl pyrophosphate synthetase to give homo-derivatives of farnesyl pyrophosphate via homo-derivatives of geranyl pyrophosphate (Scheme 1b→2b→3b, 1c→2c→3c). The maximum reaction velocities with 1b and 1c were ca. 1.0 and 0.6 relative to that observed with dimethylallyl pyrophosphate (1a). On the other hand, C_3- and C_4-compounds, (13) and trans-2-butenyl pyrophosphate (17) were not active at all, but they inhibited the reaction of dimethylallyl pyrophosphate with isopentenyl pyrophosphate.
天然有機化合物討論会の論文
1969-09-01