酵素の有機合成への応用 : とくにC-C結合生成反応について

概要

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Applications of prenyltransferases to the organic synthesis of some biologically active compounds are described. Trishomo-15, bishomo-16 and homo-farnesyl pyrophosphate 9, whose carbon skeletons are the same as those of the insect juvenile hormones, JH 0, JH I, and JH II, respectively, are synthesized by the action of farnesyl pyrophosphate synthetase of pig liver. The stereospecific C-C bond forming reaction of farnesyl pyrophosphate synthetase was efficiently utilized in the asymmetric synthesis of the stereoisomers of faranal, a trail pheromone of the Pharaoh ant, to establish the absolute configuration of the pheromone. The distribution of carbon chain length of polyprenyl pyrophosphates synthesized with solanesyl pyrophosphate synthetase of Micrococcus luteus can be controled artificially by changing the Mg++ concentration of the reaction mixture.
社団法人有機合成化学協会の論文