皮膚科アフェレシス30年の歩み(<特集>皮膚疾患とアフェレシス)

概要

論文の詳細を見る
It has been 30 years since the first successful treatment of a pemphigus vulgaris (PV) patient with plasma exchange (PE) was reported. I described the history of 30 years in dermatological apheresis. In the first 5 years, PE with the centrifugation method was performed for autoimmune bullous diseases such as PV and bullous pemphigoid (BP). In the second 5 years, double filtration plasmapheresis (DFPP) was developed and performed for those bullous diseases and toxic epidermal necrolysis (TEN). Plasmapheresis such as PE and DFPP resulted in a rapid reduction in the autoantibody titer in PV and BP, and improvement in clinical symptoms in PV, BP and TEN, remission thereby being achieved. Therefore the plasmapheresis for the treatment of PV and BP was recognized as treatment by the National Health Insurance in 1992 and that of TEN was recognized in 2006. Since 1994 immunoadsorption using a few adsorbents was tried as treatment for PV and BP, but the specific adsorbent for PV or BP has not been developed yet. Therefore the immunoadsorption method for the treatment of autoimmune bullous diseases is not established. Recently the efficacy of granulocytapheresis or leukocytapheresis for the treatment of pyoderma gangraenosum has been reported. The above-mentioned dermatological apheresis has developed over 30 years. I hope for more progress in the future.
日本アフェレシス学会の論文
2008-05-31