自己免疫性水疱症とアフェレシス : 尋常性天疱瘡

概要

論文の詳細を見る
Pemphigus vulgaris (PV) is a representative autoimmune bullous disease of the skin. Because the circulating autoantibody (PV antibody) acts as the initial trigger for blister formation, thc removal of the circulating PV antibody by apheresis appears to be an effective method for the treatment of PV. Forty-nine cases of PV were treated with apheresis by one of 5 techniclues : bag system centrifugation plasma exchange, double filtration plasmapheresis (DFPP), a combination of the two, immunoadsorption using Immusorba-TR 350 (ITR) or Immusorba-PH 350 (IPH). Three techniques of apheresis, bag system, DFPP, and ITR resulted in a rapid reduction in the PV antibody titer and an improvement in clinical symptoms, thereby allowing a lower close of corticosteroid to be administered and remission to be achieved. These findings suggest that these three techniques of apheresis were found to be an effective treatment for PV patients who had been unresponsive to conventional therapy, those in whom conventional drugs are contraindicated because of complications such as diabetes mellitus and osteoporosis, and for those who shos severe clinical manifestations. Among the three techniques examined, DFPP was found to be most preferred. In the future, the development of PV antibody specific immunoadsorbent is expected.
日本アフェレシス学会の論文
2000-10-31