自己免疫性水疱症とアフェレシス : 水疱性類天疱瘡に対する血漿交換療法(Bag式遠心分離法,二重膜濾過血漿交換療法)について

概要

論文の詳細を見る
Thirteen cases of bullous pemphigoid (BP) were treated with plasmapheresis by one of three techniques : centrifugation, double filtration plasmapheresis (DFPP), or a combination of these two techniques. Each plasmapheresis resulted in a rapid reduction in the autoantibody, titer and an improvement in clinical symptoms, allowing a low dose of corticosteroid to be administered and remission to be achieved. These findings suggest that plasmapheresis is a suitable adjunct therapy in the treatment of a severe type of BP. Among the three plasmapheresis techniques examined, DFPP was found to be the most preferred because it was not necessary to supply plasma components. Plasmapheresis was found to be an effective treatment for patients who had been unresponsive to conventional therapy, those in whom conventional drugs are contraindicated because of complications such as diabetes mellitus and osteoporosis, and those who show severe clinical manifestations.
日本アフェレシス学会の論文
2000-10-31