天疱瘡の特異的血漿吸着療法をめざして : これまでの研究の歩みと新しく開発されたチオフェンリガンド吸着材(<特集>アフェレシス療法における新しいmodality)

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We summarized the basic and clinical research on plasma adsorption for the treatment of pemphigus and reported the in vitro study of the adsorbability of pemphigus antibody by a newly developed plasma adsorbent, thiophene-ligand adsorbent. In the basic research, thiopropyl, phenylalanine, tryptophan and hexamethylene-di-isocyanate as ligands have the adsorbability of the pemphigus antibody using batchwise adsorption and column adsorption, in vitro. In the clinical research, immunoadsorption using the tryptophan ligand column is superior to immunoadsorption using the phenylalanine ligand column with respect to both the decrease of the titer of the pemphigus antibody and the improvement of clinical symptoms in the treatment of 19 patients of pemphigus vulgaris. A CL-502 column which consists of hexamethylene-di-isocyanate does not show such good results when compared to the above-mentioned procedures. In order to develop a more specific and/or selective adsorbent for the pemphigus antibody, the adsorbability of the pemphigus antibody to various adsorbents such as amino acid and thiol compounds as a ligand were examined in vitro. As a result it was shown that the pemphigus antibody was highly adsorbed to the thiophene ligand with batchwise adsorption and also in column adsorption. It was also shown that albumin and IgM were not adsorbed to the thiophene ligand with column adsorption. It is suggested that the thiophene ligand column has a relative specificity and selectivity for removing the pemphigus antibody. It is therefore suggested that plasma adsorption using a thiophene ligand column may be useful for the treatment of pemphigus vulgaris.
日本アフェレシス学会の論文
2009-10-31

天疱瘡の特異的血漿吸着療法をめざして : これまでの研究の歩みと新しく開発されたチオフェンリガンド吸着材(<特集>アフェレシス療法における新しいmodality)

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