長期療養高齢者の日常生活における唾液中分泌型免疫グロブリンAの変動

概要

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This study investigated variabilities of salivary secretory immunoglobulin A (SIgA) among elderly in long-term care facilities. The effects of upper respiratory tract infection (URTI), health-related quality of life (HRQOL) and daily life on salivary SIgA were analyzed. Subjects were 17elderly (79.9±8.0years) in long-term care facilities. Saliva samples, HRQOL (Short form-8: SF-8), URTI symptoms and daily life data were obtained from each subject every week for 12 weeks. We confirmed the intra- and inter-individual variation in salivary SIgA secretion rate in the subjects. The mean SIgA secretion rate of the highest subject was 10 times higher than that of the lowest. Four of the 17 subjects developed URTI during the 12-week study period. Their salivary SIgA secretion rate decreased and general health, physical functioning, and vitality scale for SF-8 significantly decreased compared to levels of non-infection periods. These results suggested that salivary SIgA secretion rate correlates with URTI and HRQOL in elderly.
日本体力医学会の論文
2008-04-01