Cytotoxic Constituents from Podocarpus fasciculus
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概要
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A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED_<50>=2.57 μg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.
- 2008-04-01
著者
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Kuo Y‐h
National Taiwan Univ. Taipei Twn
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Kuo Y‐h
Ghent Univ. Gent Bel
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Kuo Yu-jen
National Research Institute Of Chinese Medicine:school Of Pharmacy Taipei Medical University
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HWANG Shy-Yuan
Division of Botany, Endemic Species Research Institute
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WU Ming-Der
Food Industry Research and Development Institute
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LIAO Chia-Ching
National Research Institute of Chinese Medicine
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LIANG Yu-Han
National Research Institute of Chinese Medicine
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KUO Yao-Haur
National Research Institute of Chinese Medicine
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HO Hsiu-O
School of Pharmacy, Taipei Medical University
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Wu Ming-der
Department Of Chemistry National Sun Yat-sen University:national Research Institute Of Chinese Medic
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Kuo Yao-haur
National Res. Inst. Of Chinese Medicine Taiwan
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Ho Hsiu-o
School Of Pharmacy Taipei Medical University
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Hwang Shy-yuan
Division Of Botany Endemic Species Research Institute
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Kuo Yao-haur
National Research Institute Of Chinese Medicine:school Of Pharmacy Taipei Medical University
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Kuo Yu-haey
Department Of Biochemistry Faculty Of Medicine And Health Sciences Ghent University
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Kuo Yu-haey
Laboratory Of Physiological Chemistry Faculty Of Medicine State University Of Ghent
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Ho Hsiu-o
Coll. Of Pharmacy Taipei Medical Univ.
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