The Anti-HBsAg (Human Type B Hepatitis, Surface Antigen) and Anti-HBeAg (Human Type B Hepatitis, e Antigen) C_<18> Dibenzocyclooctadiene Lignans from Kadsura matsudai and Schizandra arisanensis

スポンサーリンク

概要

• 論文の詳細を見る

• The C_<18> dibenzocyclooctadiene lignans including three novel schizanrin F(1), G(2), H(3), along with the known kadsurarin (4), were isolated from Kadsura matsudai. A new C_<19> homolignan named schiarisanrin E(5), together with the known C_<18> lignans, gomisin B(6), G(7) and (+)-gomisin K_3(8) were obtained from Schizandra arisanensis. Gomisin B, G and (+)-gomisin K_3 showed moderate to strong activity for antihepatitis in anti-HBsAg (human type B hepatitis, surface antigen) and/or anti-HBeAg (human type B hepatitis, e antigen) tests. The structural elucidations of new compounds 1-3 and 5 were based on two-dimensional (2D) NMR techniques including COSY, HMQC, HMBC, NOESY and CD spectra. Preliminary structure-activity relationship studies for these isolated lignans are also discussed.

• 社団法人日本薬学会の論文
• 2003-11-01

著者

• Kuo Y‐h

  National Taiwan Univ. Taipei Twn

• Kuo L‐m

  National Res. Inst. Of Chinese Medicine Taipei Twn

• Kuo Y‐h

  Ghent Univ. Gent Bel

• Kuo Yu-jen

  National Research Institute Of Chinese Medicine:school Of Pharmacy Taipei Medical University

• WU Ming-Der

  Food Industry Research and Development Institute

• KUO Yao-Haur

  National Research Institute of Chinese Medicine

• Kuo Li-ming

  National Research Institute Of Chinese Medicine

• HUANG Ray-Ling

  National Research Institute of Chinese Medicine

• Huang R‐l

  National Res. Inst. Chinese Medicine Taipei Twn

• Wu Ming-der

  Department Of Chemistry National Sun Yat-sen University:national Research Institute Of Chinese Medic

• Kuo Yao-haur

  National Res. Inst. Of Chinese Medicine Taiwan

• HUNG Chia-Cheng

  National Research Institute of Chinese Medicine

• ONG Chi-Wi

  Department of Chemistry, National Sun Yat-Sen University

• Ong Chi-wi

  Department Of Chemistry National Sun Yat-sen University

• Kuo Yao-haur

  National Research Institute Of Chinese Medicine:school Of Pharmacy Taipei Medical University

• Kuo Yu-haey

  Department Of Biochemistry Faculty Of Medicine And Health Sciences Ghent University

• Kuo Yu-haey

  Laboratory Of Physiological Chemistry Faculty Of Medicine State University Of Ghent

関連論文

• Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis
• Cytotoxic Constituents from Podocarpus fasciculus
• BIOSYNTHESIS IN VITRO OF 2-(3-AMINO-3-CARBOXYPROPYL)-ISOXAZOLIN-5-ONE, THE NEUROTOXIC AMINO ACID IN LATHYRUS ODORATUS
• BIOSYNTHESIS OF β-(ISOXAZOLIN-5-ON-2-YL)ALANINE, THE PRECURSOR OF THE NEUROTOXIC AMINO ACID β-n-OXALYL-L-α, β-DIAMINOPROPIONIC ACID
• New Abietane and Seco-abietane Diterpenes from the Roots of Taiwania cryptomerioides
• A Novel Anti-HBeAg Homolignan, Taiwanschirin D from Kadsura matsudai
• P-395 Cytotoxic Constituents from Fungus, Aspergillus terreus
• Four New Nonaoxygenated C_ Dibenzocylcooctadiene Lignans from Kadsura philippinensis
• New Taxane Diterpenoids from the Roots of Taiwanese Taxus mairei
• Two Novel Sesquiterpene Lactones, Cytotoxic Vernolide-A and -B,from Vernonia cinerea
• Chromanones and Dihydrocoumarins from Calophyllum blancoi
• New Phenolic Principles from Hypericum sampsonii
• Anti-platelet Aggregation Triterpene Saponins from the Galls of Sapindus mukorossi
• P-327 Bioactive Saponins from the Fruits and Galls of Sapindus mukorossi
• A Novel Agarofuran Sesquiterpene, Celahin D from Celastrus hindsii BENTH.
• The Anti-HBsAg (Human Type B Hepatitis, Surface Antigen) and Anti-HBeAg (Human Type B Hepatitis, e Antigen) C_ Dibenzocyclooctadiene Lignans from Kadsura matsudai and Schizandra arisanensis
• A New Anti-HBeAg Lignan, Kadsumarin A, from Kadsura matsudai and Schizandra arisanensis
• A Novel Cytotoxic C-Methylated Bifiavone, Taiwanhomoflavone-B from the Twigs of Cephalotaxus wilsoniana
• A Novel Cytotoxic C-Methylated Biflavone from the Stem of Cephalotaxus wilsoniana
• A NOVEL TRISNORLUPANE, DIOSPYROLIDE, FROM DIOSPYROS MARITIMA
• Neolemnane-Type Sesquiterpenoids from a Formosan Soft Coral Paralemnalia thyrsoides
• Partial Involvement of Group I Metabotropic Glutamate Receptors in the Neurotoxicity of 3-N-Oxalyl-L-2,3-diaminopropanoic Acid(L-β-ODAP)(Pharmacology)
• Chemical Components of the Whole Herb of Mosla dianthera
• New Constituents from the Heartwood of Picea morrisonicola HAYATA
• Six Podocarpane-Type Trinorditerpenes from the Bark of Taiwania cryptomerioides
• Enzymatic Formation of 2,3-Diaminopropionic Acid, the Direct Precursor of the Neurotoxin β-ODAP, in Lathyrus sativus
• Enzymatic Synthesis of Two Isoxazolylalanine Isomers by Cysteine Synthases in Lathyrus Species
• Cladieunicellins A—E, New Eunicellins from an Indonesian Soft Coral Cladiella sp.
• Sesquiterpenoids from the Formosan Soft Coral Lemnalia flava
• New Lignans from the Heartwood of Cunninghamia lanceolata
• Simplexins J-O, Eunicellin-Based Diterpenoids from a Dongsha Atoll Soft Coral Klyxum simplex
• Antioxidant and Anti-nitric Oxide Components from Quercus glauca

もっと見る 閉じる

スポンサーリンク