Taurine Administration after Appearance of Proteinuria Retards Progression of Diabetic Nephropathy in Rats

スポンサーリンク

概要

• 論文の詳細を見る

• Oxidative stress has been postulated to be involved in the development of diabeticnephropathy. In the present study, we evaluated the effect of taurine, an endogenousantioxidant, on diabetic nephropathy by mixing it with the daily drinking water (1%w/v) of streptozotocin-induced diabetic rats from the beginning of the fourth monthafter the induction of diabetes, during which the urinary protein excretion in untreateddiabetic rats showed significant increase in comparison with nondiabetic rats. Thetaurine administration significantly suppressed further increase in urinary proteinexcretion in diabetic rats, accompanied by the reduction of mesangial extracellularmatrix expansion and TGF-β expression in the renal glomerulus. Immunohistochemicalstudy showed that taurine administration suppressed the intensified stainings to thethree different types of oxidative stress markers, such as 8-hydroxyl-2'-deoxyguanosine(8-OHdG), pentosidine, and nitrotyrosine observed in the renal tissues of untreateddiabetic rats. These findings suggest that taurine has the ability to suppress theprogression of diabetic nephropathy at least in part by its antioxidant property. Sincethis beneficial effect of taurine was obtained even if its administration was started afterthe time point when urinary protein excretion already became apparently higher thanthat of age-matched nondiabetic animals, taurine administration was potentiallyexpected to be applied in clinical field to retard the development of nephropathy indiagnosed diabetic patients.

• 神戸大学の論文

著者

• KASUGA Masato

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• Qing Yun

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Miyata Satoshi

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• KITAZAWA RIKO

  Division of Pathology, Department of Pathology&Microbiology, Kobe University Graduate School of Medi

• KITAZAWA SOHEI

  Division of Pathology, Department of Pathology&Microbiology, Kobe University Graduate School of Medi

• Kasuga Masato

  Division Of Diabetes And Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kob

• Kitazawa Riko

  Division Of Molecular Pathology Department Of Pathology And Microbiology Kobe University Graduate Sc

• Kitazawa Riko

  Division Of Molecular Pathology Department Of Biomedical Informatics Kobe University Graduate School

• Kitazawa Sohei

  Division Of Molecular Pathology Department Of Pathology And Microbiology Kobe University Graduate Sc

• Kitazawa Sohei

  Division Of Molecular Pathology Department Of Biomedical Informatics Kobe University Graduate School

• Miyata Satoshi

  Division Of Cell Biology Kihara Institute For Biological Research Yokohama City University

• Miyata Satoshi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Higo Satomi

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Kasuga Masato

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Higo Satomi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Miyata Satoshi

  Division of Bioinformatics, Genome Center of the JFCR

関連論文

• Methylglyoxal Induces Prostaglandin E2 Production in Rat Mesangial Cells
• Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
• The IHPK1 gene is disrupted at the 3p21. 31 breakpoint of t(3 ; 9) in a family with type 2 diabetes mellitus
• MDR1 T-129C Polymorphism can be Predictive of Differentiation, and Thereby Prognosis of Colorectal Adenocarcinomas in Japanese(Biopharmacy)
• Different Contribution of CYP2C19 in the in Vitro Metabolism of Three Proton Pump Inhibitors
• MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer
• MDR1 C3435T Polymorphism Is Predictive of Later Onset of Ulcerative Colitis in Japanese(Biopharmacy)
• Lack of Association of LRP5 and LRP6 Polymorphisms with Type 2 Diabetes Mellitus in the Japanese Population
• Insulin-stimulated Fusion of GLUT4 Vesicles to Plasma Membrane is Dependent on Wortmannin-sensitive Insulin Signaling Pathway in 3T3-L1 Adipocytes
• Association Study of the Effect of WFS1 Polymorphisms on Risk of Type 2 Diabetes in Japanese Population
• Association of Serum MCP-1 Concentration and MCP-1 Polymorphism with Insulin Resistance in Japanese Individuals with Obese type 2 Diabetes
• FRS-069 PDK-1 Plays Essential Roles in Cell Size Regulation, Beta-adrenergic Response and Cell Survival in the Heart(Heart Failure, Cardiac Remodeling and Cardiomyopathy 1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Analysis of factors affecting increase in bone mineral density at lumbar spine by bisphosphonate treatment in postmenopausal osteoporosis
• Protein Kinase Cα Is Implicated in Cholecystokinin-Induced Activation of 70-kd S6 Kinase in AR42J Cells
• Comparison of Synthetic DNA Templates with Authentic cDNA Templates in Terms of Quantification by Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction(Analytical Biochemistry)
• Expression of Laminin-5 Enhances Tumorigenicity of Human Fibrosarcoma Cells in Nude Mice
• Effects of Polymorphisms of MDR1, MRP1, and MRP2 Genes on Their mRNA Expression Levels in Duodenal Enterocytes of Healthy Japanese Subjects(Biopharmacy)
• Hepatic Failure and Enhanced Oxidative Stress in Mitochondrial Diabetes
• Functional Giant Parathyroid Cyst with High Concentration of CA19-9 in Cystic Fluid
• Expression of parathyroid hormone-related protein (PTHrP) in multiple myeloma
• A Case of Hypothalamic Panhypopituitarism with Empty Sella Syndrome : Case Report and Review of the Literature
• A Transgenic Mouse Line with a 58-kb Fragment Deletion in Chromosome 11E1 That Encompasses Part of the Fam20a Gene and Its Upstream Region Shows Growth Disorder
• Insulin-induced GLUT4 Movements in C2C12 Myoblasts : Evidence against a Role of Conventional Kinesin Motor Proteins
• N-Acetyltransferase 2 Genotype-Related Sulfapyridine Acetylation and Its Adverse Events
• Optimal Dose of Omeprazole for CYP2C19 Extensive Metabolizers in Anti-Helicobacter pylori Therapy : Pharmacokinetic Considerations
• ARGON PLASMA COAGULATION FOR TREATMENT OF HEMORRHAGIC RADIATION GASTRODUODENITIS
• Fetal hydrops associated with spontaneous premature closure of ductus arteriosus
• Application trials of in situ hybridization at the electron microscopic level
• Lung carcinosarcoma with liposarcoma element : Autopsy case
• MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma
• Expression of Trypsin in Human Cancer Cell Lines and Cancer Tissues and Its Tight Binding to Soluble Form of Alzheimer Amyloid Precursor Protein in Culture
• In Situ Hybridization on Calcified Tissue : Detection of RANKL mRNA in Mouse Osteolytic Bone Lesions
• Experimental Studies on the Role of Fructose in the Development of Diabetic Complications
• Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells
• Taurine Administration after Appearance of Proteinuria Retards Progression of Diabetic Nephropathy in Rats
• Insulin Efficiently Stores Triglycerides in Adipocytes by Inhibiting Lipolysis and Repressing PGC-1α Induction.
• WS2-5 ISH on Calcified Tissue : Expression of Receptor Activator of NF-κB Ligand(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
• Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma
• OJ-260 The effect of oral charcoal adsorbent (AST-120) on the progression of cardiac abnormalitites in chronic kidney disease(OJ44,Kidney/Renal Circulation/CKD 2 (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
• Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association
• Efficient Genetic Analysis of Microdissected Samples by Agarose-Bead Method: Alterations of β-Catenin Gene in Fundic Gland Polyp and Heterotopic Gastric Mucosa of Duodenum
• MeCP2 Expression and Promoter Methylation of Cyclin D1 Gene Are Associated with Cyclin D1 Expression in Developing Rat Epididymal Duct

もっと見る 閉じる

スポンサーリンク