Association Study of the Effect of WFS1 Polymorphisms on Risk of Type 2 Diabetes in Japanese Population

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概要

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• Mutations of WFS1 gene cause Wolfram syndrome, which is a rare autosomalrecessive disorder characterized by juvenile diabetes mellitus, optic atrophy, deafnessand diabetes insipidus. The product encoded by WFS1 gene, wolframin, could beinvolved in ER stress response causing β-cell loss through impaired cell cycleprogression and increased apoptosis. Recently, polymorphisms in the WFS1 gene werestrongly associated with type 2 diabetes in Caucasians. The aim of the present studywas to examine whether the variants of WFS1 are associated with risk of type 2diabetes in Japanese individuals. Four single nucleotide polymorphisms, rs6446482,rs12511742, rs1801208 (R456H) and rs734312 (H611R) were genotyped in a total of 536diabetic patients and 398 nondiabetic control subjects. Among the four variants,rs12511742 showed a marginal association with susceptibility to type 2 diabetes (oddsratio = 1.32, 95% confidence interval = 1.02-1.71, P = 0.033). Carriers of the risk alleleat rs12511742 exhibited lower pancreas β-cell function (P = 0.017). However, thisassociation disappeared after adjustment for sex, age and BMI (Adjusted P = 0.24).Although we found no evidence for a substantial effect of WFS1 polymorphisms on riskof type 2 diabetes or clinical characteristics of diabetic subjects in Japanese population,this gene is still a good candidate for a type 2 diabetes susceptibility gene, potentially,through impaired insulin secretion.

• 神戸大学の論文

著者

• Tsunoda Tatsuhiko

  Research Center For Animal Life Science Shiga University Of Medical Science

• Horikawa Yukio

  神戸大学 大学院医学研究科内科学講座糖尿病･代謝･内分泌内科学分野

• Horikawa Yukio

  Department Of Diabetes And Endocrinology Gifu University School Of Medicine

• MIYAKE Kazuaki

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• HIROTA Yushi

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• KASUGA Masato

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• Horikaw Yukio

  Department Of Diabetes And Endocrinology Division Of Molecule And Structure Gifu University School O

• Hirota Yushi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Hirota Yushi

  神戸大学 大学院医学研究科内科学講座糖尿病･代謝･内分泌内科学分野

• Hinokio Yoshinori

  東北大学病院 糖尿病代謝科

• Kasuga Masato

  神戸大学 医学系研究科糖尿病代謝内分泌内科学

• ZENIBAYASHI MASAKO

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• TERANISHI TETSUYA

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• KOUYAMA KUNICHI

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• SAKAGUCHI KAZUHIKO

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Mita Masaki

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Tanaka T

  Laboratory For Cardiovascular Diseases Center For Genomic Medicine Riken

• Teranishi Tetsuya

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Teranishi Tetsuya

  Department Of Internal Medicine Harima Hospital Of Ishikawajima-harima Heavy Industries Health Insur

• Sakaguchi Kazuhiko

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Kasuga Masato

  Division Of Diabetes And Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kob

• Mita Masaki

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Mita Masaki

  Division Of Diabetes Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kobe Un

• Horikawa Yukio

  Lab. Of Medical Genomics Biosignal Genome Resource Center Inst. For Molecular And Cellular Regulatio

• Miyake Kazuaki

  神戸大学 医学研究科糖尿病･代謝･内分泌内科学

• Kouyama Kunichi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Zenibayashi Masako

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• KUMASAKA Natsuhiko

  Laboratory for Medical Informatics, Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN)

• Miyake Kazuaki

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Graduate School Of Medicine

• Sakaguchi Kazuhiko

  Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Hirota Yushi

  Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine

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