Insulin Efficiently Stores Triglycerides in Adipocytes by Inhibiting Lipolysis and Repressing PGC-1α Induction.
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概要
- 論文の詳細を見る
White adipose tissue (WAT) is important as an energy reservoir in mammals, butthe precise mechanism by which energy storage in WAT is controlled remains unclear.It is well known that representative anabolic hormone insulin efficiently storestriglyceride in adipocytes. We showed that insulin inhibited β-agonist-induced lipolysisat least in part by inhibiting phosphorylation of perilipin and hormone-sensitive lipase(HSL) in 3T3-L1 adipocytes. Furthermore, insulin inhibited β-agonist-induced increaseof PGC-1α expression, which is important for mitochondrial biogenesis and energyexpenditure. These results suggest the possibility that insulin efficiently storestriglyceride in adipocytes by decreasing lipolysis and repressing energy expenditure.
- 神戸大学の論文
著者
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KASUGA Masato
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University
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Tamori Yoshikazu
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit
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Tamori Yoshikazu
Division Of Diabetes And Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kob
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Kasuga Masato
Division Of Diabetes And Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kob
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Nishino Naonobu
Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, K
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Nishino Naonobu
Division Of Diabetes And Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kob
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