Association of Serum MCP-1 Concentration and MCP-1 Polymorphism with Insulin Resistance in Japanese Individuals with Obese type 2 Diabetes

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概要

• 論文の詳細を見る

• Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) secreted byadipocytes is a member of the CC chemokine family and plays a pivotal role in theinflammatory process. A polymorphism, the -2518 A/G of MCP-1 gene, has beenassociated with type 2 diabetes, type 1 diabetes, parameters of insulin resistance andobesity. Therefore, we investigated the effects of MCP-1 single nucleotidepolymorphisms (SNPs) on the susceptibility to type 2 diabetes or insulin resistance inthe Japanese population. We also assessed the correlation between serum MCP-1concentration and other clinical characteristics in Japanese type 2 diabetic subjects.The serum MCP-1 concentration was significantly correlated with HOMA-IR and thevisceral fat area, but not with BMI. Although there was no association between thisSNP and type 2 diabetes, the -2518A/G polymorphism was associated with the serumMCP-1 concentration. In subgroup analysis, Japanese obese diabetic -2518AA carriershad a higher MCP-1 concentration and increased insulin resistance than obese diabetic-2518G carriers. These data indicated that the MCP-1 polymorphism was associatedwith insulin resistance in Japanese obese diabetic subjects and that MCP-1 wasimplicated in the pathogenesis of insulin resistance, especially associated with obesity,in humans.

• 神戸大学の論文

著者

• Tsunoda Tatsuhiko

  Research Center For Animal Life Science Shiga University Of Medical Science

• Horikawa Yukio

  神戸大学 大学院医学研究科内科学講座糖尿病･代謝･内分泌内科学分野

• Horikawa Yukio

  Department Of Diabetes And Endocrinology Gifu University School Of Medicine

• MIYAKE Kazuaki

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• HIROTA Yushi

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• KASUGA Masato

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• Horikaw Yukio

  Department Of Diabetes And Endocrinology Division Of Molecule And Structure Gifu University School O

• Hirota Yushi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Hirota Yushi

  神戸大学 大学院医学研究科内科学講座糖尿病･代謝･内分泌内科学分野

• Hinokio Yoshinori

  東北大学病院 糖尿病代謝科

• Kasuga Masato

  神戸大学 医学系研究科糖尿病代謝内分泌内科学

• ZENIBAYASHI MASAKO

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• TERANISHI TETSUYA

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• KOUYAMA KUNICHI

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• SAKAGUCHI KAZUHIKO

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Tamori Yoshikazu

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Kanda Hajime

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Ohara Takeshi

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• Tanaka T

  Laboratory For Cardiovascular Diseases Center For Genomic Medicine Riken

• Tamori Yoshikazu

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Tamori Yoshikazu

  Division Of Diabetes And Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kob

• Teranishi Tetsuya

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Teranishi Tetsuya

  Department Of Internal Medicine Harima Hospital Of Ishikawajima-harima Heavy Industries Health Insur

• Sakaguchi Kazuhiko

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Kasuga Masato

  Division Of Diabetes And Digestive And Kidney Diseases Department Of Clinical Molecular Medicine Kob

• Kanda Hajime

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Ohara Takeshi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Horikawa Yukio

  Lab. Of Medical Genomics Biosignal Genome Resource Center Inst. For Molecular And Cellular Regulatio

• Miyake Kazuaki

  神戸大学 医学研究科糖尿病･代謝･内分泌内科学

• Kouyama Kunichi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Zenibayashi Masako

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Ohara Takeshi

  Division Of Diabetes And Endocrinology Hyogo Prefectural Kakogawa Medical Center

• KUMASAKA Natsuhiko

  Laboratory for Medical Informatics, Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN)

• Miyake Kazuaki

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Graduate School Of Medicine

• Sakaguchi Kazuhiko

  Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Hirota Yushi

  Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine

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