A Transgenic Mouse Line with a 58-kb Fragment Deletion in Chromosome 11E1 That Encompasses Part of the Fam20a Gene and Its Upstream Region Shows Growth Disorder
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概要
- 論文の詳細を見る
Growth disorder is an umbrella term for a range of abnormal growth patterns, such as unusually fast or slow growth in infants or children. The causes of growth disorder include hormonal irregularities, chronic disease, complications during pregnancy or genetic conditions. A complex trait such as body size is influenced by multiple genes as well as environmental factors, giving rise to a continuous spectrum of phenotypes. This causal complexity makes discovery of the genetic determinants of growth disorder rather difficult. We here report our discovery of a transgenic mouse line exhibiting growth disorder, which we happened to discover in the course of generating transgenic mice expressing a viral gene. Although these mice did not express any corresponding viral mRNA or protein due to a deletion in the transgene, they showed slow growth in the 5 weeks after birth and ceased growing thereafter, while maintaining a weight equivalent to that of 3-week-old normal mice. Histopathological analysis of the organs of these mice revealed that malnutrition and metabolic disorder occurred at 5 weeks after birth in the liver. Genetic analysis has revealed that the growth disorder is associated with a 58-kb fragment deletion in chromosome 11E1 that encompasses part of the Fam20a gene and part of its upstream region. The present study thus points out for the first time the possible link between Fam20a mutation and growth disorder.
- 神戸大学の論文
著者
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Nakaji Miyuki
神戸大学医学系研究科
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Ide Yoshi-hiro
神戸大学 医学研究科微生物学
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Nakaji Miyuki
神戸大学 医系研究 糖尿病代謝消化器腎臓内科学
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Shoji Ikuo
Division of Microbiology, Kobe University Graduate School of Medicine
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Nagano-Fujii Motoko
Division of Microbiology, Kobe University Graduate School of Medicine
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Hotta Hak
Division of Microbiology, Kobe University Graduate School of Medicine
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Hotta Hak
Kobe Univ. Graduate School Of Medicine Kobe Jpn
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Hotta Hak
Division Of Microbiology Department Of Genome Sciences Kobe University Graduate School Of Medicine
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Nagano-fujii Motoko
Division Of Microbiology Kobe University Graduate School Of Medicine
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KITAZAWA SOHEI
Division of Pathology, Department of Pathology&Microbiology, Kobe University Graduate School of Medi
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Chunying An
Division of Microbiology, Kobe University Graduate School of Medicine
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Ide Yoshi-Hiro
Division of Microbiology, Kobe University Graduate School of Medicine
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Chunying An
Division Of Microbiology Kobe University Graduate School Of Medicine
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Kitazawa Sohei
Division Of Molecular Pathology Kobe University Graduate School Of Medicine
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Kitazawa Sohei
Division Of Molecular Pathology Department Of Biomedical Informatics Kobe University Graduate School
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Hotta H
Departments Of Microbiology Kobe University Graduate School Of Medicine
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Shoji Ikuo
Division Of Microbiology Center For Infectious Diseases Kobe University Graduate School Of Medicine
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Ide Yoshi-hiro
Division Of Microbiology Center For Infectious Diseases Kobe University Graduate School Of Medicine
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