Autoimmune Thrombocytopenic Purpura during Pegylated Interferon α Treatment for Chronic Hepatitis C

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概要

• 論文の詳細を見る

• We describe a 72-year-old woman with chronic hepatitis C and autoimmune thrombocytopenic purpura (AITP) during pegylated interferon (PEG-IFN) α. Immunoglobulin G and antinuclear antibody were 2,113 mg/dL and 1,280 at the start, respectively. A liver biopsy negated autoimmune hepatitis. After a 48-week combination therapy with ribavirin, PEG-IFN α-2a was administered. At the 30th month, the platelet count was decreased to 1.1×104/μL. Bone marrow biopsy disclosed normocellular marrow compatible with AITP. The platelet-associated IgG (PAIgG) titer rose to 500 ng/107 cells. Corticosteroid therapy was successful, and the platelet count and PAIgG titer reverted to 6.4×104/μL and 57.3 ng/107 cells, respectively.

著者

• Ando Kenji

  Department of Cardiology, Kokura Memorial Hospital

• KIM Soo

  Department of Gastroenterology, Kobe Asahi Hospital

• MITA Keiji

  Department of Gastroenterology, Kobe Asahi Hospital

• IMOTO Susumu

  Department of Gastroenterology, Kobe Asahi Hospital

• KUDO Masatoshi

  Department of Gastroenterology, Kinki University Medical School of Medicine

• NAKAJIMA Taisuke

  Department of Gastroenterology, Kobe Asahi Hospital

• HONG Hyun

  Department of Gastroenterology, Kobe Asahi Hospital

• FUKUDA Katsumi

  Department of Gastroenterology, Kobe Asahi Hospital

• Lee Yeong

  Department of Gastroenterology, Kobe Asahi Hospital

• Nakashima Keiichi

  Department of Gastroenterology, Kobe Asahi Hospital

• Shoji Ikuo

  Division of Microbiology, Kobe University Graduate School of Medicine

• Nagano-Fujii Motoko

  Division of Microbiology, Kobe University Graduate School of Medicine

• Hotta Hak

  Division of Microbiology, Kobe University Graduate School of Medicine

• Hayashi Yoshitake

  Center for Infectious Diseases (CID), Kobe University Graduate School of Medicine

• Hotta Hak

  Division Of Microbiology Department Of Genome Sciences Kobe University Graduate School Of Medicine

• Mita Keiji

  Department Of Chemistry Faculty Of Science Shizuoka University

• Nagano-fujii Motoko

  Division Of Microbiology Kobe University Graduate School Of Medicine

• Imoto Susumu

  Department Of Gastroenterology Kobe Asahi Hospital

• Fukuda Katsumi

  Department Of Gastroenterology Kobe Asahi Hospital

• Nakajima Taisuke

  Department Of Gastroenterology Kobe Asahi Hospital

• Ando Kenji

  Department Of Applied Chemistry Nagoya Institute Of Technology

• Hong Hyun

  Department Of Gastroenterology Kobe Asahi Hospital

• Kim Soo

  Department Of Advanced Technology Fusion Konkuk University

• Shoji Ikuo

  Division Of Microbiology Center For Infectious Diseases Kobe University Graduate School Of Medicine

• Kudo Masatoshi

  Department Of Gastroenterology And Hepatology Kinki University Faculty Of Medicine

• Kudo Masatoshi

  Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases

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