702 ハイドロキシアパタイト超薄膜による人工関節軟骨への生体親和性付与(G02-3 バイオマテリアル,G02 バイオエンジニアリング)

概要

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In developing artificial cartilage, made from poly(vinyl alcohol) hydrogel (PVA-H), it is important to develop a method for imparting cell attachment to certain areas of PVA-H surface because PVA-H itself has very poor biocompatibility. In this experiment, hydroxyapatite (HA) thin film 300nm thick was deposited by pulsed laser deposition technique on PVA-H. And the interaction between PVA-H and mouse fibroblast was examined by a cell culture method. The cell attachment on HA coated PVA-H (water content 33%) showed the maximum that was as high as commonly used tissue culture dish. Although higher water content (53%) PVA-H, this technique was effective in the improvement of cell attachment. Pulsed laser deposition is novel technique for quick and firm attachment between PVA-H and the underlying bone.
社団法人日本機械学会の論文
2006-09-15