Antimycobacterial Activity of Cinnamate-Based Esters of the Triterpenes Betulinic, Oleanolic and Ursolic Acids
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概要
- 論文の詳細を見る
Betulinic acid, oleanolic acid and ursolic acid have been modified at the C-3 position to cinnamate-based esters and in vitro antimycobacterial activity against Mycobacterium tuberculosis H_<37>Ra has been determined. The results indicated that modification of the parent structures of betulinic acid, oleanolic acid and ursolic acid to the p-coumarate and, in the case of the latter two triterpenes, the ferulate ester analogues resulted in high antimycobacterial activity. Structure-activity relationships within the lupane, oleanane and ursane analogues and between these triterpenes are discussed.
- 公益社団法人日本薬学会の論文
- 2008-02-01
著者
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Suksamrarn Apichart
Department Of Chemistry And Center Of Excellence For Innovation In Chemistry Faculty Of Science Ramk
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Bremner John
School Of Chemistry University Of Wollongong
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CHOKCHAISIRI Ratchanaporn
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ra
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TANACHATCHAIRATANA Tanud
Department of Chemistry, Faculty of Science, Ramkhamhaeng University
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Chokchaisiri Ratchanaporn
Dep. Of Chemistry And Center Of Excellence For Innovation In Chemistry Fac. Of Sci. Ramkhamhaeng Uni
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Chokchaisiri Ratchanaporn
Department Of Chemistry And Center Of Excellence For Innovation In Chemistry Faculty Of Science Ramk
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Tanachatchairatana Tanud
Department Of Chemistry Faculty Of Science Ramkhamhaeng University
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