Bioactive Constituents of the Root Bark of Artocarpus rigidus subsp. rigidus

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概要

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• Investigation of the chemical constituents of the root bark of Artocarpus rigidus BLUME suhsp. rigidus has led to the isolation of six, structurally diverse phenolic compounds. These included two new compounds with modified skeletons, the flavonoid 7-demethylartonol E (1) and the chromone artorigidusin (2), together with four known phenolic compounds, the xanthone artonol B (3), the flavonoid artonin F (4), the flavonoid cycloartobiloxanthone (5), and the xanthone artoindonesianin C (6). Compounds 1, 4, and 5 exhibited antiplasmodial activity against Plasmodium falciparum. All compounds showed antimycobacterial activity against Mycobacterium tuberculosis, with 4 being the most active compound (MIC 6.25μg/ml). Compounds 5 and 6 were active against KB cells, whereas 2, 5, and 6 showed varying toxicity to BC cells. Compounds 1-3, 5, and 6 were active in the NCIH187 cytotoxicity assay, with 3 being the most active compound (IC_<50> 1.26μg/ml).

• 公益社団法人日本薬学会の論文
• 2006-10-01

著者

• Suksamrarn Apichart

  Department Of Chemistry And Center Of Excellence For Innovation In Chemistry Faculty Of Science Ramk

• SUKSAMRARN Sunit

  Department of Chemistry, Faculty of Science, Srinakharinwirot University

• Aroonrerk Nuntana

  Department Of Stomatology Faculty Of Dentistry Srinakharinwirot University

• Aroonrerk Nuntana

  Department Of Microbiology Mahidol University

• NAMDAUNG Umalee

  Department of Chemistry, Faculty of Science, Ramkhamhaeng University

• DANWISETKANJANA Kannawat

  National Center for Genetic Engineering and Biotechnology

• SAENBOONRUENG Janya

  National Center for Genetic Engineering and Biotechnology

• ARJCHOMPHU Wisit

  Khlong Muangkluang non-hunting area, Department of National Park, Wild Life and Plants, Ministry of

• Namdaung Umalee

  Department Of Chemistry Faculty Of Science Ramkhamhaeng University

• Arjchomphu Wisit

  Khlong Muangkluang Non-hunting Area Department Of National Park Wild Life And Plants Ministry Of Nat

• Suksamrarn Sunit

  Department Of Chemistry Faculty Of Science Srinakharinwirot University

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