Cytotoxic Prenylated Xanthones from the Young Fruit of Garcinia mangostana

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概要

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• Three new prenylated xanthones, mangostenones C (1), D (2), and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Compound 1 showed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth (KB), breast cancer (BC-1), and small cell lung cancer (NCI-H187), with IC_<50> values of 2.8, 3.53, and 3.72μg/ml, respectively. Among the isolates, α-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells with an IC_<50> value of 0.92μg/ml, an activity greater than that of the standard drug ellipticine (IC_<50>=1.46μg/ml). Compound 12 also showed the highest activity against KB cells, while gar-tanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC_<50> values of 2.08μg/ml and 1.08μg/ml.

• 公益社団法人日本薬学会の論文
• 2006-03-01

著者

• Suksamrarn A

  Department Of Chemistry Faculty Of Science Ramkhamhaeng University

• Suksamrarn Apichart

  Department Of Chemistry And Center Of Excellence For Innovation In Chemistry Faculty Of Science Ramk

• SUKSAMRARN Sunit

  Department of Chemistry, Faculty of Science, Srinakharinwirot University

• KOMUTIBAN Orapin

  Department of Chemistry, Faculty of Science, Srinakharinwirot University

• RATANANUKUL Piniti

  Department of Chemistry, Faculty of Science, Srinakharinwirot University

• CHIMNOI Nitirat

  Chulabhorn Research Institute

• LARTPORNMATULEE Nattapat

  Bioassay Research Facility of National Center for Genetic Engineering and Biotechnology, National Sc

• Ratananukul Piniti

  Department Of Chemistry Faculty Of Science Srinakharinwirot University

• Suksamrarn Sunit

  Department Of Chemistry Faculty Of Science Srinakharinwirot University

• LARTPORNMATULEE Nattapat

  Bioassay Research Facility of National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency

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