Ceanothane- and Lupane-Type Triterpenes with Antiplasmodial and Antimycobacterial Activities from Ziziphus cambodiana

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概要

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• One new and eight known ceanothane- and lupane-type triterpenes were isolated from the root bark of Zizi-phus cambodiana PIERRE (Rhamnaceae). Based on spectral analyses, the structure of the new compound was elucidated as 3-O-(4-hydroxy-3-methoxybenzoyl) ceanothic acid (3-O-vanillylceanothic acid) (1), while the known compounds were identified as lupeol (2), betulinaldehyde (3), betulinic acid (4), 2-O-E-p-coumaroyl alphitolic acid (5), alphitolic acid (6), zizyberanalic acid (7), zizyberenalic acid (8) and ceanothic acid (9). Compounds 1, 5 and 8 exhibited significant in vitro antiplasmodial activity against the parasite Plasmodium falciparum, with inhibitory concentration (IC_<50>) values of 3.7, 0.9 and 3.0μg/ml, respectively. Compounds 1 and 3-8 showed an-timycobacterial activity against Mycobacterium tuberculosis with respective MIC values of 25, 25, 25, 12.5, 50, 50 and 100μg/ml.

• 公益社団法人日本薬学会の論文
• 2006-04-01

著者

• Suksamrarn Apichart

  Department Of Chemistry And Center Of Excellence For Innovation In Chemistry Faculty Of Science Ramk

• Suksamrarn Sunit

  Department Of Chemistry Faculty Of Science Srinakharinwirot University

• PANSEETA Panomwan

  Department of Chemistry, Faculty of Science, Srinakharinwirot University

• KUNCHANAWATTA Soykam

  Department of Chemistry, Faculty of Science, Srinakharinwirot University

• DISTAPORN Thanomsin

  Department of Chemistry, Faculty of Science, Srinakharinwirot University

• RUKTASING Saovaluk

  National Center for Genetic Engineering and Biotechnology, National Science and Technology Developme

• Panseeta Panomwan

  Department Of Chemistry Faculty Of Science Srinakharinwirot University

• Ruktasing Saovaluk

  National Center For Genetic Engineering And Biotechnology National Science And Technology Developmen

• Distaporn Thanomsin

  Department Of Chemistry Faculty Of Science Srinakharinwirot University

• Kunchanawatta Soykam

  Department Of Chemistry Faculty Of Science Srinakharinwirot University

• Suksamrarn Sumit

  Department of Chemistry, Faculty of Science, Srinakharinwirot University

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