Effects of Low-dose Irradiation on Enhancement of Immunity by Dendritic Cells

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概要

• 論文の詳細を見る

• Low-doses of irradiation have been reported to have beneficial effects, particularly anti-tumor effects. In this paper, we show the effects of the low-dose irradiation on T cell activation induced by dendritic cells (DCs). DCs, which had been pre-irradiated at 0.02-1.0 Gy from a ^<137>Cs source, were cultured with allogeneic T cells, and the proliferation of T cells was then examined. The 0.05Gy-pre-irradiated DCs showed the highest proliferation capacity of T cells. The 0.05Gy-irradiation does not augment the expression of major histocompatibility complexes (MHCs) or costimulatory molecules on DCs, as with non-irradiated DCs or 1Gy-irradiated DCs, but does augment the production of IL-2, IL-12 and IFN-γDCs. These results suggest that the low-dose irradiation augments T cell-activation capacity through cytokine production by DCs, which might shift naive helper T cells to Th1 cells.

• 日本放射線影響学会の論文
• 2007-01-15

著者

• ADACHI Yasushi

  First Department of Pathology, Kansai Medical University

• SHIGEMATSU Akio

  First Department of Pathology, Kansai Medical University

• IKEHARA Susumu

  First Department of Pathology, Kansai Medical University

• Suzuki Yasuhiro

  First Department of Medicine, Asahikawa Medical College

• Adachi Yasushi

  The First Department of Pathology, Kansai Medical University

• Imamura Masahiro

  Department Of Radiology

• Suzuki Yasuhiro

  First Department Of Pathology Kansai Medical University

• Ikehara Susumu

  First Department Of Pathology Kansai Medical University

• Ikehara Susumu

  First Department Of Pathology Kansai Medical University:regeneration Research Center For Intractabel

• Ikehara Susumu

  The First Department Of Pathology Kansai Medical University

• Adachi Yasushi

  First Department Of Pathology Kansai Medical University

• Adachi Yasushi

  First Department Of Pathology Kansai Medical University:regeneration Research Center For Intractabel

• Iwasaki Masayoshi

  Second Department of Internal Medicine, Kansai Medical University

• Shigematsu Akio

  First Department Of Pathology Kansai Medical University

• IWASAKI Masayoshi

  First Department of Pathology, Kansai Medical University

• NAKANO Keiji

  First Department of Pathology, Kansai Medical University

• KOIKE Yasushi

  First Department of Pathology, Kansai Medical University

• MUKAIDE Hiromi

  First Department of Pathology, Kansai Medical University

• Imamura Masahiro

  Department Of Environmental Science Central Research Institute Of Electric Power Industry (criepi)

• Imamura Masahiro

  Department Of Hematology And Oncology Hokkaido University Graduate School Of Medicine

• Iwasaki Masayoshi

  First Department Of Pathology Kansai Medical University

• KOIKE(KIRIYAMA) Naoko

  First Department of Pathology, Kansai Medical University

• Iwasaki Masayoshi

  Department Of Hematology And Oncology Hokkaido University Graduate School Of Medicine

• Nakano Keiji

  First Department Of Pathology Kansai Medical University

• Koike Yasushi

  First Department Of Pathology Kansai Medical University

• Mukaide Hiromi

  First Department Of Pathology Kansai Medical University

• Iwasaki Masayoshi

  Second Department Of Internal Medicine Kansai Medical University

• Adachi Yasushi

  First Department Of Internal Medicine Sapporo Medical University

• Koike(kiriyama) Naoko

  First Department Of Pathology Kansai Medical University

• Adachi Yasushi

  The First Department Of Pathology Kansai Medical University

• Koike-Kiriyama Naoko

  First Department of Pathology, Kansai Medical University

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