Granulocyte-Colony Stimulating Factor Increases Donor Mesenchymal Stem Cells in Bone Marrow and Their Mobilization Into Peripheral Circulation but Does Not Repair Dystrophic Heart After Bone Marrow Transplantation
スポンサーリンク
概要
- 論文の詳細を見る
Background Hereditary disordered cardiac muscle could be replaced with intact cardiomyocytes derived from genetically intact bone marrow (BM)-derived stem cells. Methods and Results Cardiomyopathic mice with targeted mutation of δ-sarcoglycan gene underwent intra-BM-BM transplantation (IBM-BMT) from transgenic mice expressing green fluorescence protein. The host BM and the peripheral blood were completely reconstituted by donor-derived hematopoietic cells by IBM-BMT. Treatment with granulocyte-colony stimulating factor (G-CSF) markedly increased donor-derived mesenchymal stem cells (MSC) in the BM and their mobilization into the peripheral blood after IBM-BMT. Treatment with isoproterenol (iso) for 7 days caused myocardial damage and left ventricular (LV) dysfunction in the cardiomyopathic mice. Co-treatment with iso and G-CSF increased donor BM cell recruitment to the heart and temporarily improved LV function in the cardiomyopathic mice with or without IBM-BMT. However, the cardiac muscle was not replaced with donor BM-derived cardiomyocytes in the cardiomyopathic mice with or without IBM-BMT, and this was associated with no improvement of LV function of mice aged 20 weeks. Conclusions These results suggest that G-CSF enhances engraftment of donor MSC in the BM and their mobilization into the peripheral circulation after IBM-BMT but MSC recruited to the heart do not differentiate into cardiomyocytes and do not repair the dystrophic heart.
- 社団法人日本循環器学会の論文
- 2008-07-20
著者
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Otani Hajime
2ndary Division Of Internal Medicine Kansai Medical University
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Tatsumi Kimiko
The Department of Pediatrics, Kansai Medical University
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Otani Hajime
The Second Department of Internal Medicine, Kansai Medical University
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Sato Daisuke
The Second Department of Internal Medicine, Kansai Medical University
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Enoki Chiharu
The Department of Thoracic and Cardiovascular Surgery, Kansai Medical University
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Iwasaka Toshiji
The Second Department of Internal Medicine, Kansai Medical University
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Imamura Hiroji
The Department of Thoracic and Cardiovascular Surgery, Kansai Medical University
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Taniuchi Shoichiro
The Department of Pediatrics, Kansai Medical University
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Kaneko Kazunari
The Department of Pediatrics, Kansai Medical University
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Adachi Yasushi
The First Department of Pathology, Kansai Medical University
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Ikehara Susumu
The First Department of Pathology, Kansai Medical University
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Iwasaka T
Second Department Of Internal Medicine Kansai Medical University
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Iwasaka Toshiji
The Cardiovascular Center Kansai Medical University
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Sato Daisuke
2ndary Division Of Internal Medicine Kansai Medical University
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Izuoka Toshio
The Second Department Of Internal Medicine Kansai Medical University
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Izuoka Toshio
関西医科大学 2内
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Enoki Chiharu
Department Of Thoracic And Cardiovascular Surgery Kansai Medical University
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Enoki Chiharu
The Department Of Cardiovascular Surgery Shizuoka Red Cross Hospital
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Satoh Daisuke
2ndary Division Of Internal Medicine Kansai Medical University
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Ikehara Susumu
First Department Of Pathology Kansai Medical University:regeneration Research Center For Intractabel
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Ikehara Susumu
The First Department Of Pathology Kansai Medical University
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Adachi Yasushi
First Department Of Pathology Kansai Medical University
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Adachi Yasushi
First Department Of Pathology Kansai Medical University:regeneration Research Center For Intractabel
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Imamura Hiroji
Department Of Thoracic And Cardiovascular Surgery Kansai Medical University
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Imamura Hiroji
Department Of Thoracic And Cardiovascular Surgery Kansai Medical University Hospital
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Imamura Hiroji
The Department Of Thoracic And Cardiovascular Surgery Kansai Medical University Hospital
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Tatsumi Kimiko
The Department Of Pediatrics Kansai Medical University
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Ibaraki Toshihiko
Department Of Pharmacology Osaka Medical College
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Kaneko Kazunari
The Department Of Pediatrics Kansai Medical University
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Taniuchi Syoichirou
The Department Of Pediatrics Kansai Medical University
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Ibaraki Toshihiko
Second Department Of Internal Medicine Kansai Medical University
-
Sato Daisuke
The Second Department Of Internal Medicine Kansai Medical University
-
Iwasaka Toshiji
The Second Department Of Internal Medicine Kansai Medical University
-
Otani Hajime
The Second Department Of Internal Medicine Kansai Medical University
-
Kaneko Kazunari
The Department Of Pediatrics Juntendo University School Of Medicine
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Iwasaka Toshiji
The 2nd Dept. Of Intern. Med. Kansai Med. School
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Iwasaka Toshiji
Cardiovascular Division Second Department Of Internal Medicine Kansai Medical University
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Adachi Yasushi
The First Department Of Pathology Kansai Medical University
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Imamura Hiroji
Department Of Thoracic And Cardiovascular Surgery Kansai Medical University Hirakata Hospital
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