Impact of Lipid-Lowering Therapy With Pitavastatin, a New HMG-CoA Reductase Inhibitor, on Regression of Coronary Atherosclerotic Plaque : A 3-Dimensional Intravascular Ultrasound Study
スポンサーリンク
概要
- 論文の詳細を見る
Background Recent lipid-lowering trials have reported that statin therapy may retard progression or stimulate regression of human coronary plaque. In the present study volumetric intravascular ultrasound (IVUS) analyses were performed to investigate the effect of pitavastatin, a newly developed statin, on regression of human coronary plaque. Methods and Results Eighty-two patients matched for age and gender from 870 consecutive patients undergoing IVUS guided percutaneous coronary intervention were retrospectively assigned to either lipid-lowering therapy (n=41; pitavastatin 2mg/day) or control group (n=41; diet only). Serial volumetric IVUS analyses of a matched left main coronary arterial site were performed. A significant reduction in low-density lipoprotein-cholesterol (LDL-C) level of 33.2% (p<0.001) was observed in the pitavastatin group. Plaque volume index (PVI) was significantly reduced in the pitavastatin group (10.6±9.4% decrease) compared with the control group (8.1±14.0% increase, p<0.001). There were positive correlations between the percent change in the PVI and follow-up LDL-C level (r=0.500, p<0.001) and the percent change in LDL-C level (r=0.479, p<0.001). Conclusion Lipid-lowering therapy with pitavastatin induced significant coronary plaque regression, associated with a significant reduction in the LDL-C level. The percent change in the PVI showed a significant positive correlation with the percent change in LDL-C level. (Circ J 2007; 71 : 1678-1684)
- 社団法人日本循環器学会の論文
- 2007-10-20
著者
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Ito Takayuki
Department Of Health Sciences Nagoya University School Of Medicine
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Itoh Takayuki
Department Of Cardiology Aichi Medical University
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OZAKI Yukio
Division of Cardiology, Department of Internal Medicine, Fujita Health University, School of Medicin
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WASEDA Katsuhisa
Center for Research in Cardiovascular Interventions, Stanford University
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Waseda Katsuhisa
Center For Research In Cardiovascular Interventions Stanford University Medical Center
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Waseda Katsuhisa
Center For Research In Cardiovascular Interventions Stanford University
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Ozaki Yukio
Department Of Cardiology Fujita Health University School Of Medicine
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Wakida Yasushi
Department Of Cardiology Aichi Medical University
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Wakida Yasushi
The 3rd Department Of Internal Medicine Aichi Medical University
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WAKITA Yoshinori
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
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Ozaki Yukio
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
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Ozaki Yukio
Divisoin Of Cardiology Fujita Health University School Of Medicine
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Takashima Hiroaki
Department of Cardiology,Aichi Medical University School of Medicine
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Kuroda Yasuo
Department of Cardiology,Aichi Medical University School of Medicine
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Asai Kenji
Department of Cardiology,Aichi Medical University School of Medicine
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Kuhara Yasushi
Department of Cardiology,Aichi Medical University School of Medicine
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Yasukawa Tatsuya
Yasukawa Clinic & Aichi Medical University
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Yasukawa Tatsuya
Yasukawa Clinic
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Takagi Kazuaki
Department Of Cardiology Aichi Medical University
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Asai Kenji
Department Of Cardiology Aichi Medical University
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Kuhara Yasushi
Department Of Cardiology Aichi Medical University
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Takashima Hiroaki
Department Of Cardiology Aichi Medical University
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Wakita Yoshinori
Department Of Cardiology Aichi Medical University
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Wakita Yoshinori
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Kosaka Takashi
Department of Cardiology, Aichi Medical University, School of Medicine
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Ozaki Yukio
Division Of Acute Coronary Syndrome Aichi Council Of Advanced Emergency Care
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Ozaki Yukio
Aichi Medical University
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Ito Takayuki
Division Of Cardiology Aichi Medical University School Of Medicine
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Asai Kenji
Department Of Bioregulation Research Nagoya City University
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Ito Takayuki
Department Of Cardiology Aichi Medical University
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Wakamatsu Yoshitaka
2nd Dept.of Internal Med. Nagoya Univ.school Of Med.
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Wakamatsu Yoshitaka
Department Of Cardiology Aichi Medical University
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Itoh Takayuki
Department Of Cardiology Aichi Medical University School Of Medicine
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Ozaki Yukio
Division Of Cardiology Fujita Health University Hospital
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KOSAKA Takashi
Department of Cardiology, Aichi Medical University
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KURODA Yasuo
Department of Cardiology, Aichi Medical University
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