ラット下肢骨格筋に対する長期間の脱トレーニングの影響

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The effect of long term (53wk.) de-training on the hind limb muscle was investigated in the female Fischer344 rats. The animals were divided into four groups : 23-week-old control (23C), 23-week-old trained (23T), 77-week-old de-trained (77DT) and 77-week-old control (77C) groups. Animals in-group 23T or 77DT were trained with treadmill running (〜77%V0_2max, 15%, 60 min/day and 5 days/wk) for 10 weeks. The animals ingroup 77DT were housed and were provided with food and water ad libitum for 53 weeks after the last training. The results showed that the relative tibialis anterior (TA) muscle weight in group 23T was significantly higher than group 23C. There was no significant difference in the relative TA, lateral gastrocnemius (LGAS) muscle weight between 77DT and 77C groups. The protein content of the TA muscle in group 23T was higher than that in group 23C. There was no significant difference in protein content between 77DT and 77C groups. There was no significant difference in concentration of total protein between each group at all condition. These results indicate that training effects was lost for a long term de-training ; the protein concentrations of the TA and LGAS muscle are not affected with training or de-training in rats.
久留米大学の論文