Five New neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata with Cytotoxic Activities
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概要
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Five new neo-clerodane diterpenoid alkaloids, named scutebarbatine G(1), 6,7-di-O-nicotinoylscutebarbatine G(2), 6-O-nicotinoyl-7-O-acetylscutebarbatine G(3), scutebarbatine H(4) and 7-O-nicotinoylscutebarbatine H(5) were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1-5 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC_<50> values in the range 3.4-8.5μM.
- 2007-08-01
著者
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Shen Li
Key Laboratory Of Marine Drugs Chinese Ministry Of Education Institute Of Marine Drug And Food
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Wang Gong-fu
School Of Pharmaceutical Science Yantai University
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Chen Meng
School Of Pharmaceutical Science Yantai University
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Dai Sheng-jun
School Of Pharmaceutical Science Yantai University
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LIU Ke
School of Pharmaceutical Science, Yantai University
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SHEN Li
School of Pharmaceutical Science, Yantai University
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Liu Ke
School Of Pharmaceutical Science Yantai University
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