Four New neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata with Cytotoxic Activities

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概要

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• Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures were elucidated by spectral analyses (UV, IR, FABMS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC_<50> values in the range 3.9-7.8μM.

• 2006-06-01

著者

• Jiang Yong-tao

  School Of Pharmaceutical Science Yantai University

• Shen Li

  Key Laboratory Of Marine Drugs Chinese Ministry Of Education Institute Of Marine Drug And Food

• Chen Meng

  School Of Pharmaceutical Science Yantai University

• Dai Sheng-jun

  School Of Pharmaceutical Science Yantai University

• LIU Ke

  School of Pharmaceutical Science, Yantai University

• SHEN Li

  School of Pharmaceutical Science, Yantai University

• Liu Ke

  School Of Pharmaceutical Science Yantai University

関連論文

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