New Diels-Alder Type Adducts from Morus macroura and Their Anti-oxidant Activities
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概要
- 論文の詳細を見る
Fractionation of the ethanolic extract of the stem bark of Morus macroura resulted in the isolation of four new Diels-Alder type adducts, named guangsangons K-N (1, 2, 5, 6), together with two known compounds, mulberrofuran G (3) and K (4). Their structures were determined on the basis of spectroscopic analyses and chemical methods. Furthermore, by means of ^1H-NMR variable temperature experiments and the Cotton curves in the circular dichroism (CD) spectra, the stereochemistry of four new compounds was elucidated. The isolated new compounds showed good activity on anti-oxidant in vitro, with the inhibitory rates of MDA being from 91.8 to 100.0% at concentrations of 10^<-5> mol/l.
- 公益社団法人日本薬学会の論文
- 2004-10-01
著者
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Chen Ruo-yun
Key Lab. Of Bioactive Substances And Resources Utilization Of Chinese Herbal Medicine Ministry Of Ed
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Wang Yong-hong
Institute Of Medicinal Chemistry Hoshi University
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Wang Ying-hong
Key Lab. Of Bioactive Substances And Resources Utilization Of Chinese Herbal Medicine (ministry Of E
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Yu De-Quan
Institute of Materia Medica, Chinese Academy of Medical Sciences
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He Wen-yi
Institute Of Materia Medica Chinese Academy Of Medical Sciences & Peking Union Medical College
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Wang Ying-hong
Institute Of Materia Medica Chinese Academy Of Medical Sciences & Peking Union Medical College
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DAI Sheng-Jun
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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WU Yan
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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CHEN Ruo-Yun
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
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Chen Ruo-yun
Institute Of Materia Medica Chinese Academy Of Medical Sciences & Peking Union Medical College
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Yu De-quan
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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Yu De-quan
Institute Of Materia Medica Chinese Academy Of Medical Sciences & Peking Union Medical College
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Dai Sheng-jun
School Of Pharmaceutical Science Yantai University
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Dai Sheng-jun
Institute Of Materia Medica Chinese Academy Of Medical Sciences & Peking Union Medical College
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Wu Yan
State Key Lab. Of Drug Res. Inst. Of Materia Medica Shanghai Institutes For Biological Sciences Chin
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Wu Yan
Institute Of Materia Medica Chinese Academy Of Medical Sciences & Peking Union Medical College
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