Dietary Effects of n-3 Eicosapentaenoic Acid on Essential Fatty Acid-deficiency Symptoms of Rats(Food & Nutrition)

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概要

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• The effects of eicosapentaenoic acid (EPA, 20 : 5n-3) on essential fatty acid (EFA)-deficient rats were studied. After low growth and scaly dermatitis in the hind legs due to dietary EFA deficiency were induced by feeding rats an EFA-free 25% casein diet (25C) containing 30% hydrogenated coconut oil with 1% cholesterol (HCO・CHOL) for 8 weeks, they received the 25C diet with 0.19 or 0.57% EPA ethyl ester concentrate added, or 0.02% or 0.38% linoleic acid (LA, 18 : 2n-6) concentrate (Exp. I), and the HCO・CHOL meal including any one of 0.25, 0.50, or 1.00% EPA concentrate, and 0.12 and 0.48% LA concentrate (Exp. II) for an additional 6 weeks. When EFA-deficient rats were fed the EPA in both experiments, body weight was gained to almost reach those of the 0.38 or 0.48% LA-fed group (control), and the dermal symptoms of the hind legs were relieved, though the degree of healing was less than those of the controls. The ratios of eicosatrienoic acid (20 : 3n-9) to arachidonic acid (20 : 4n-6) characteristically increased due to EFA deficiency were reduced to the level of the control in the liver and heart by addition of the EPA concentrate.

• 社団法人日本農芸化学会の論文
• 1989-12-23

著者

• YOSHIDA Makoto

  Faculty of Fisheries, Nagasaki University

• Takeuchi Hisanao

  Faculty Of Agriculture Shizuoka University

• Muramatsu Keiichiro

  Faculty Of Home Economics Nagoya Women's University

• INOUE Jun

  Faculty of Agriculture, Shizuoka University

• WAKATAKE Shoichi

  Faculty of Agriculture, Shizuoka University

• ICHIMURA Yasushi

  Faculty of Agriculture, Shizuoka University

• EMA Toshiya

  Faculty of Agriculture, Shizuoka University

• Ema Toshiya

  Faculty Of Agriculture Shizuoka University

• Wakatake Shoichi

  Faculty Of Agriculture Shizuoka University

• Yoshida M

  Kyocera Corp.

• Yoshida Makoto

  Faculty Of Agriculture Tokyo University Of Agriculture And Technology

• Inoue Jun

  Faculty Of Agriculture Shizuoka University

• Ichimura Yasushi

  Faculty Of Agriculture Shizuoka University

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