The Mechanism of Bone Resorption Induced by Epiregulin, a Member of EGF Family(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
- 論文の詳細を見る
We investigated the effect of epiregulin (EPR) and EOF on the bone resorption using mice bones and cells. Both EPR and EGF enhanced bone resorption in ^<45>Ca-prelabeled parietal bone without affecting osteoclast differentiation. These growth factors also enhanced the pit formation by femur-derived osteoclast-rich fraction without increasing the number of the osteoclasts in a NS-398 (a COX-2 inhibitor)- sensitive manner. Furthermore, mature osteoclasts, differentiated from RANKL-stimulated RAW264.7 cells, induced pit formation with a longer time of EPR in a gefitinib (an EGFR tyrosinekinase inhibitor-sensitive manner. These findings suggest that both EPR and EGF acted on osteoblasts to enhance bone resorption indirectly. In addition, EPR is suggested to have a direct stimulating pathway through the activation of EGFR on mature osteoclasts leading to bone resorption.
- 硬組織再生生物学会の論文
著者
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Sugiyama Eiji
Department Of Internal Medicine 1 Faculty Of Medicine University Of Toyama
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Sugiyama Eiji
Department Of Internal Medicine Faculty Of Pharmaceutical Sciences Toyama Medical
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Miyahara Tatsuro
Department Of Human Sience Faculty Of Pharmaceutical Sciences Toyama Medical
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OCHIAI Hiroshi
Department of Human Science, Faculty of Medicine, University of Toyama
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NEMOTO Nobuo
Faculty of Pharmaceutical Science, Toyama Medical and Pharmaceutical University
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IMANISHI Nobuko
Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University
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Sakuma Tsutomu
Faculty Of Medicine And Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical
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Ochiai Hiroshi
Department Of Human Science Faculty Of Medicine Toyama Medical And Pharmaceutical University.
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Nemoto Nobuo
Faculty Of Medicine And Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical
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Katoh Terutaka
Department of Public Health, Faculty of Pharmaceutical Sciences, Toyama Medical
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Ito Sumiyo
Faculty of Medicine, and Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medica
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Aono Mitsunori
Faculty of Medicine, and Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medica
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Mikami Yasutaro
Faculty of Medicine, and Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medica
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Komurasaki Toshi
Pharmaceutical University, and Molecular Biology Laboratory, Medicinal Research Laboratories, Taisho
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Ito Sumiyo
Faculty Of Medicine And Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical
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Aono Mitsunori
Faculty Of Medicine And Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical
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Katoh Terutaka
Department Of Public Health Faculty Of Medicine University Of Toyama
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Katoh Terutaka
Department Of Public Health Faculty Of Pharmaceutical Sciences Toyama Medical
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Mikami Yasutaro
Faculty Of Medicine And Department Of Toxicology Faculty Of Pharmaceutical Sciences Toyama Medical
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Komurasaki Toshi
Pharmaceutical University And Molecular Biology Laboratory Medicinal Research Laboratories Taisho Ph
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Ochiai Hiroshi
Department Of Biochemistry And Biotechnology Faculty Of Agriculture And Life Science Hirosaki Univer
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Ochiai Hiroshi
Department Of Human Sience Faculty Of Pharmaceutical Sciences Toyama Medical
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Imanishi Nobuko
Department Of Human Sience Faculty Of Pharmaceutical Sciences Toyama Medical
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Sugiyama Eiji
Department Of Clinical Immunology And Rheumatology Hiroshima University
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