光に安定な貴金属カルボン酸塩錯体の構造多様性と生理活性(2005年度神奈川大学総合理学研究所助成共同研究)

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Using light-stable dimeric silver(I) carboxylate precursors {[Ag(Hpyrrld)]_2}_n formed with chiral and racemic forms of 2-pyrrolidone-5-carboxylic acid (H_2pyrrld) ligand, six novel light-stable, triphenylphosphinesilver(I) complexes consisting of both a hard Lewis base (O atom) and a soft Lewis base (P atom) were prepared, i.e. [Ag_2(R-Hpyrrld)_2(H_2O)(PPh_3)_2]・H_2O 1,[Ag(R-Hpyrrld)(PPh_3)_2]_2 2, [Ag_2(S-Hpyrrld)_2(H_2O)(PPh_3)_2]・H_2O 3, [Ag(S-Hpyrrld)(PPh_3)_2]_2 4,{[Ag(R,S-Hpyrrld)(PPh_3)]_2}_n 5 and [Ag(R,S-Hpyrrld)(PPh_3)_2] 6. Their solid-state and solution structures were unequivocally characterized with elemental analysis, TG/DTA, FTIR, X-ray structure analysis, molecular weight measurements in EtOH with the vaporimetric method, solution (^1H, ^<13>C, ^<31>P) NMR and solid-state ^<31>P CPMAS NMR spectroscopy. Two sets of enantiomeric complexes were isolated as (1 and 3) and (2 and 4). X-ray crystallography revealed that these complexes possessed different Ag-O bonding modes, depending on the number of PPh_3 ligands and the chirality of the Hpyrrld ligand. Complexes 1-6 behaved as a monomeric species in EtOH and CD_2Cl_2. Antimicrobial activites by silver(I) complexes in the water-suspension system against selected bacteria, yeast and molds were significantly correlated with the number of coordinating PPh_3 ligands per silver(I) atom in the complexes.
神奈川大学の論文
2006-05-25