広い抗菌活性スペクトルを示すヒスチジン銀(Ⅰ)錯体の合成、構造と投与後のバクテリアの電子顕微鏡観察

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2010年度神奈川大学総合理学研究所共同研究助成論文Silver (I) histidinates are very unique silver (I) complexes obtained by the reactionof silver oxide and histidines (H2his) in water. Reactions of silver oxide and amino acids gave several silver (I) histidinates, i.e., water-soluble {[Ag(L-Hhis)]2}n (L-1) and water-insoluble [Ag(L-Hhis)]n (L-2) and [Ag2(L-Hhis)(D-Hhis)]n (DL-1) depending on reaction conditions such as the reaction time, selecting ligand (L-H2his or L- and D-H2his) and pH. The donor atom of the three complexes was nitrogen and they exhibited a wide spectrum of effective antimicrobial activities against both Gram-positive and Gram-negative bacteria (Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa) as well as yeasts (Candida albicans and Saccharomyces cerevisiae) and molds (Aspergillus niger and Penicillium citrinum). Observation of four bacteria before and after administration of L-1 was carried out using TEM to investigate whether L-1, interacts outside or inside of bacteria.
2011-06-30