Potent Cytotoxic Rocaglamide Derivatives from the Fruits of Amoora cucullata
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概要
- 論文の詳細を見る
Two new rocaglamide derivatives, 1-O-formylrocagloic acid (1) and 3'-hydroxy rocagloic acid (2), together with five known compounds, rocaglaol (3), rocagloic acid (4), 3'-hydroxymethylrocaglate (5), 1-O-formylmethyl rocaglate (6), and methylrocaglate (7), were isolated from the fruits of Amoora cucullata. Their structures were elucidated by spectroscopic methods. Compounds 1-3, 6, and 7 exhibited potent cytotoxicity against KB, BC, and NCI-H187 cell lines, whereas 4 and 5 showed selective cytotoxicity against NCI-H187 cell line.
- 公益社団法人日本薬学会の論文
- 2006-09-01
著者
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Kato Shigeru
Department of Internal Medicine, Fujita Health University School of Medicine
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Chantrapromma Kan
Inst. Of Res. And Dev. Walailak Univ.
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Chantrapromma Kan
School Of Science Walailak University
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CHUMKAEW Parinuch
School of Science and Research Unit of Natural Products Utilization, Walailak University
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Chumkaew Parinuch
School Of Science And Research Unit Of Natural Products Utilization Walailak University
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Kato Shigeru
Department Of Applied Chemistry Faculty Of Engineering Seikei University
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Chantrapromma Kan
School of Science and Research Unit of Natural Products Utilization, Walailak University
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