Cytotoxic and Antimalarial Prenylated Xanthones from Cratoxylum cochinchinense

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概要

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• A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), α-mangostin (5), β-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods. Compounds 2 and 4-7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC_<50> values ranging from 0.65 to 5.2μg/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC_<50> values of 3.2, 4.9, 7.2 and 2.6μg/ml, respectively.

• 公益社団法人日本薬学会の論文
• 2006-05-01

著者

• Laphookhieo Surat

  School Of Science Mae Fah Luang University

• Syers John

  School Of Science Mae Fah Luang University

• KIATTANSAKUL Rattana

  Department of Chemistry, Faculty of Science, Prince of Songkla University

• CHANTRAPROMMA Kan

  School of Science, Walailak University

• Chantrapromma Kan

  School Of Science Walailak University

• Kiattansakul Rattana

  Department Of Chemistry Faculty Of Science Prince Of Songkla University

• Chantrapromma Kan

  School of Science and Research Unit of Natural Products Utilization, Walailak University

関連論文

• Cytotoxic and Antimalarial Prenylated Xanthones from Cratoxylum cochinchinense
• Potent Cytotoxic Rocaglamide Derivatives from the Fruits of Amoora cucullata
• A New Triterpenoid Ester from the Fruits of Bruguiera parviflora

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