Ultraviolet Irradiation-induced Denaturation of Elastic Fibers in the Structure and the Sensitivity to Pancreas Elastase
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概要
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We investigated the changes of the chemical structures of elastic fibers by ultraviolet (UV) irradiation and the specificity to elastase in this study. UV irradiation destroyed the structure of elastic fibers and produced some soluble peptides including β-elastoprotein-like peptide. From the results of amino acid analysis, it was thought that elastic fibers were degraded in the area near the cross-linkings and the oiled coils were released into the water-soluble fraction. The peptides including cysteine were also released. These observations suggest the lack of stability and elastic function of the elastic fibers irradiated with UV. In elastic fibers irradiated with UV, oxidative denaturation of the fibers proceeded, because the carbonyl contents were increased in the insoluble elastic fibers. The contents of hydrophobic amino acids such as glycine, alanine, and valine were also increased in elastic fibers. These changes caused the resistance of elastic fibers to the pancreas elastase. The lowering of the sensitivity of elastic fibers to elastase would be related with the development of actinic elastosis.
- 沼津工業高等専門学校の論文
- 2006-01-31
著者
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Yoshino Kyoji
Department Of Chemistry & Biochemistry
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KOMURA Sadaaki
Institute of Applied Biochemistry
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