Isolation of Antioxidative Compounds from Brazilian Propolis : 3,4-Dihydroxy-5-prenylcinnamic Acid, a Novel Potent Antioxidant
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概要
- 論文の詳細を見る
One new and 11 previously known antioxidative compounds were isolated from Brazilian propolis. The new compound was determined as 3,4-dihydroxy-5-prenylcinnamic acid (3-[3,4-dihydroxy-5-(3-methyl-2-butenyl)-phenyl]-2-(E)-propenoic acid) by various physical analyses (MS, IR, ^1H-NMR, ^<13>C-NMR, and 2D-NMR). The inhibitory activity of each compound against peroxidation of linoleic acid in a micelle solution was measured. We found that the novel compound possessed the highest potency (IC_<50>, 0.17 μM) among them and was more effective than butylated hydroxytoluene (BHT; IC_<50>, 0.36 μM) under the experimental conditions employed. Among the isolated antioxidative compounds, 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C; IC_<50>, 0.44 μM) was found to be most abundant in Brazilian propolis.
- 1999-11-15
著者
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YAGI Kunio
Institute of Applied Biochemistry, Yagi Memorial Park
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OHISHI Nobuko
Institute of Applied Biochemistry
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Hayashi Katsuhiro
Institute Of Applied Biochemistry Yagi Memorial Park
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Ohishi N
Institute Of Applied Biochemistry Yagi Memorial Park
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Yagi K
Institute Of Applied Biochemistry Yagi Memorial Park
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KOMURA Sadaaki
Institute of Applied Biochemistry
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ISAJI Noriko
Institute of Applied Biochemistry, Yagi Memorial Park
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Isaji Noriko
Institute Of Applied Biochemistry Yagi Memorial Park
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Komura Sadaaki
Institute Of Applied Biochemistry Yagi Memorial Park
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Yagi Kunio
Institute Of Applied Biochemistry Yagi Memorial Park
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