出血時間測定による抗血小板剤の効力評価の試み

概要

論文の詳細を見る
We examined the relationship between bleeding time and anti-platelet medicines prescribed to 472 ischemic heart disease patients in Gifu Prefectural Gifu Hospital. The average bleeding time of the patients taking aspirin (81-200mg) and ticlopidine (100-200mg) concomitantly was significantly longer than that of those in the control group, while that for patients taking aspirin alone or cilostazol (100-200mg) and aspirin concomitantly was not significantly different from that of control. There was no significant correlation between the dosage (mg/kg) of each medicine and the bleeding time. In 14 patients, the bleeding time was not prolonged when the administration of platelet medicines was started or additional anti-platelet medicines were given. The presence of patients who did not respond to anti-platelet medicines, and the difficulty of achieving reproducibility in measured bleeding times might have lead to the absence of a significant correlation between the dosage of medicines and the bleeding time. Our findings therefore suggest that it may be difficult to evaluate the effectiveness of adjusting dosages of anti-platelet medicines from the bleeding time.
日本医療薬学会の論文
2006-09-10