再発死亡したリンパ節転移陰性直腸癌における微小リンパ節転移の予後因子としての意義についての検討

概要

論文の詳細を見る
We investigated the prognostic value of lymph node micrometastases in histologically-node-negative rectal cancer patients who died of recurrence. The 231 lymph nodes from 15 patients with histologically node-negative rectal cancer who died of recurrence were examined. The lymph nodes were stained with antibody to cytokeratins 7 and 8 (CAM5.2) and examined for the presence of occult lymph node metastases. Micrometastases were detected in 25 lymph nodes (10.8%) from 10 (66.7%) patients. The rate of lymph node micrometastasis was significantly higher in the male patients, but no significant differences were found in another clinicopathological factors. There were no significant differences in recurrence sites between the two groups, and there were no significant differences between the survival curves of them. The median survival time was 55 months among the patients without cytokeratin-positive nodes, 38 months among the patients with 3 or fewer cytokeratin-positive nodes, and 26 months among the patients with 4 or more cytokeratin-positive nodes. The survival time of the patients with 4 or more cytokeratin-positive nodes was shorter than among patients with no or 3 or fewer cytokeratin-positive nodes. In conclusion, 67% of node-negative rectal cancer patients who died of recurrence had lymph node micrometastases. The presence of micrometastases may affect the prognosis of rectal cancer.
新潟大学の論文
2003-11-10