The maintenance of genome integrity is tissue-specific
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概要
- 論文の詳細を見る
In order to understand how mutagens behave and act in vivo, it is important to understand how the integrity of the genome is maintained and protected in each specific tissue. Although several lines of evidence suggest that the systems used to protect and maintain the genome can change or are modified during cellular differentiation processes, and when cells alter their status from a proliferating to a non-proliferating state, data on individual tissues is very limited. Recent studies on the age-dependent accumulation of spontaneous mutations in transgenic mice clearly indicate that there is tissue-specificity when examining genome maintenance and protection. The genome is most unstable in epithelial tissues of the small and large intestine when compared to 13 other organs and tissues. The genome is highly protected in brain, skin and testis. Studies of the molecular nature of specifie mutations suggest the presence of unique tissue-specific mechanisms leading to the formation of mutations in specific tissues. Studies of mutations in DNA repair gene deficient mice have shown that some of the genes involved in mismatch repair are indispensable in many tissues for the maintenance of the genome. The Xpa and Xpc genes involved in nucleotide excision repair have also been shown to be important in some tissues. However, the studies reported to date are only a beginning, and a complete comprehensive picture of the maintenance and repair of the genomic integrity in individual tissues remains to be developed.
- 日本環境変異原学会の論文
- 2006-02-28
著者
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Ono Tetsuya
Department of Internal Medicine, Kure Kyosai Hospital
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Ono Tetsuya
東北大学 生命科学研究科
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Ono T
Department Of Cell Biology Graduate School Of Medicine Tohoku University
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KOMURA JUN-ICHIRO
Department of Cell Biology, Graduate School of Medicine, Tohoku University
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IKEHATA HIRONOBU
Department of Cell Biology, Graduate School of Medicine, Tohoku University
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Uehara Yoshihiko
Department of Cell Biology, Graduate School of Medicine, Tohoku University
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Komura Jun-ichiro
Department Of Cell Biology Graduate School Of Medicine Tohoku University
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Ono Tetsuya
Graduate School Of Medicine Tohoku Univ.
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Ono Tetsuya
Department Of Cell Biology Graduate School Of Medicine Tohoku University
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Ikehata Hironobu
Department Of Cell Biology Graduate School Of Medicine Tohoku University
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Uehara Yoshihiko
Department Of Cell Biology Graduate School Of Medicine Tohoku University
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Ono Takashi
Research Center Of Health Physical Fitness And Sports Nagoya University
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Ono Tetsuya
Department of Biotechnology, The University of Tokyo
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