Streptozotocin遺伝性糖尿病ICRマウスの歯周組織における病理組織学的および組織化学的研究

概要

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The permanent diabetes in the ICR mice was produced by an intraperitoneal injection of 80 μg/g streptozotocin (NSC-37917). The periodontal tissues of the six-month-old mice with streptozotocin hereditary diabetes, that were the seventh generation of the above ICR mice, were investigated histopathologically and histochemically. 1. The ridges of the gingival epithelium was irregular and hyperplastic. The acid phosphatase activity decreased in this epithelium. 2. In the gingival lamina propria, dilatation and hyperplasia of blood vessel were observed. There was an increase in number of the mast cells and a marked release of granules from these cells. The acid phosphatase activity increased in the lamina propria. 3. In the periodontal membrane, the arrangement of the fibers was irregular and both acid and alkaline phosphatase activities increased. 4. With an appearence of the osteoclasts, the alveolar bone showed an osteoclastic resorption on its surface, and the β-glucuronidase activity increased in the osteoclasts.
特定非営利活動法人日本歯周病学会の論文
1979-03-28