Effect of Gamma-oryzanol on Atheroma Formation in Hypercholesterolemic Rabbits
スポンサーリンク
概要
- 論文の詳細を見る
The anti-oxidant action of ferulic acid in gamma-oryzanol was tested in hypercholesterolemic rabbits to determine its effects on the development of atherosclerosis. Eighteen male New Zealand white rabbits were fed a diet containing 1% cholesterol with or without 1% gamma-oryzanol for 10 weeks. The anti-oxidant effect was assessed by the degree of resistance of low density lipoprotein (LDL) to oxidation by copper sulfate and the effect of the copper oxidized LDL on the incorporation of oleate into cholesteryl ester by mouse peritoneal macrophages. In addition, the levels of plasma cholesterol, triglyceride and lipid peroxide were measured before, during and at the end of cholesterol loading. The amount of free ferulic acid and gamma-oryzanol in plasma and LDL and the area of aortic atherosclerotic plaques were determined. It was found that oleate incorporation into cholesteryl ester by macrophages was significantly reduced in the gamma-oryzanol-treated group compared to the non-treated group, and that the reduction was via a mechanism independent of anti-oxidant action. However, no differences were found in the levels of plasma cholesterol, triglyceride, lipid peroxide or in the areas of atherosclerotic plaques between the two groups. It was concluded that gamma-oryzanol has little or no preventive effects on atherosclerosis in rabbits.
- 東海大学の論文
著者
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HIRAMATSU Kazuko
Department of Internal Medicine, Tokai University School of Medicine
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Hiramatsu Kazuko
Department Of Medicine School Of Medicine Tokai University
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Izumi Shin-ichi
Department of Histology and Cell Biology, Nagasaki University School of Medicine
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NAKANE Paul
Department of Cell Biology, School of Medicine, Tokai University
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TANI Takeshi
Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd.
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KIMURA Yukio
Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd.
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Hiramatsu Kazuko
Department Of Internal Medicine Kawasaki Kyodo Hospital
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Nakane Paul
Department Of Anatomy Nagasaki University School Of Medicine
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Tani Takeshi
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Izumi Shin-ichi
Department Of Anatomy Nagasaki University School Of Medicine
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Kimura Y
Kyushu Univ. Fukuoka Jpn
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Kimura Yukio
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Nakane Paul
Department Of Anatomy (iii) Nagasaki University School Of Medicine
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NAKANE Paul
Department of Anatomy, Nagasaki University School of Medicine
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