主要振戦周波数を用いた生理的および病理的振戦の解析(2部生体の特性)

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The vibration called tremor is widely seen in human beings. In the medical field, the many diseases display tremor which is typically represented by Parkinson's disease and essential tremor. The number of patients with Parkinson's disease is about 100,000 in Japan and will increase in the future. Parkinson's disease has three typical signs, namely tremor, rigidity, and hypokinesia. Tremor is the most dominant symptom in the triad. It is difficult to discriminate Parkinson's disease from several other diseases simulating Parkinson's symptoms. Medical treatment is often effective in Parkinson's disease, but in general these are transitory. In this study, we tried to discriminate these diseases by measuring tremor using accelerometers. We developed a measuring and analyzing system for tremor in the upper limbs using accelerometers, which were put on both hands. The posture of the subjects during measuring their tremor was as follows: Subjects sat on a chair and put their elbows on a desk. We placed their forearms at an angle of 45°from the horizontal plane. Tremor signals were analyzed and the dominant frequency was calculated as "main frequency". The severity of the tremor can be quantified by the spectra. We adopted the main frequency and its tremor strength as two tremor indicators. The measuring system was applied to 42 patients with Parkinson's disease (mean age, 73.8 years), 5 patients with drug-induced Parkinsonism (mean age, 72.6 years) and 36 patients with essential tremor (mean age, 67.8 years). The system could significantly discriminate the drug-induced Parkinsonian tremor from the other two types of tremor diseases (p<0.01). The degree of tremor could be quantified using an engineering index, namely, the power of the main frequency. We studied the relationship between age and the symptoms of the Parkinson's disease and essential tremor. The results were as follows: In Parkinson's disease the frequency decreased with increasing length of tremor history. In essential tremor, the main frequency decreased and the power of the frequency increased with the age of the patients. We tried to control tremor using the biofeedback technique in three healthy subjects. An effect on tremor frequency was observed during the biofeedback training. The power of high-frequencies tremors (which we defined as tremors at frequency between 5 and 15 [Hz]) increased in all patients. We assume it possible to control the patients' tremors using the biofeedback technique. Biofeedback is considered to be a useful therapy for all patients with tremor, because it is not invasive and it doesn't require any medicines such as L-Dopa.
バイオメカニズム学会の論文
1998-11-25

主要振戦周波数を用いた生理的および病理的振戦の解析(2部生体の特性)

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主要振戦周波数を用いた生理的および病理的振戦の解析(2部 生体の特性)

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主要振戦周波数を用いた生理的および病理的振戦の解析(2部生体の特性)