筋ジストロフィー患者のマイクロバイブレーションに関する研究(1部ヒトのバイオメカニクス)

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The purpose of this study was to elucidate the muscular influence of microvibration (MV) and to apply MV to the evaluation of a medical index for dystrophy patients. Subjects were 10 myotonic dystrophy patients (MD; 7 males and 3 females, 43.5±8.2 years), five limb-girdle patients in progressive muscular dystrophy (LG; 4 males and 1 female, 38.6±12.7 years), and 12 normal subjects (males, 21.0±2.0 years) being treated for comparison. Muscular function data for the patients (function stage, grip strength, and pinching force) were measured before the experiment. Metric data (length and girth of upper limb) were also measured. Subjects sat on chairs and laid their right forearm on an elbow rest. MV's at eyelid, m. biceps brachii, and right thenar were detected by MT-3 T. Physiological tremor at the palm was measured by a miniature accelerator. The order used in the experiment was resting state for two minutes, maximum voluntary contraction (MVC), the holding of 60% MVC for one minute, and resting state for three minutes. The MV and physiological tremor data for each one minute were analyzed by (a) integrated amplitude of five bands in the range from 2 to 30Hz, and (b) the first peak frequency of power spectrum. The evaluations of the amplitude and peak frequency and the data of the muscular functions and metrics were all studied by principal component analysis in order to find correlations among the data. MV for eyelid, m. biceps brachii, and thenar showed the characteristic main bands, i. e., delta band (2-4Hz), alpha band (8-13Hz), and theta band (4-8Hz), respectively. MV amplitude for the patients was lower than that, for normal subjects. MV amplitude for the normal subjects increased during 60% MVC, but this phenomenon was not recognized in the patients. Similar results were shown in the first peak frequency: The peak frequency for the patients waslower by 2 Hz than that for the normal controls and was hardly influenced by conditions like rest or load. Differences in peak frequency and amplitude between MD patients and normal controls were at a level of 1% significance. The results of principal component analysis denoted that the function stage closely correlated to the peak frequency of MV at thenar and m. biceps brachii and to the metrics of the upper limb. The above results showed that MV was affected by muscles. Therefore, the influence of the neuromuscular system (i. e., gamma motor system) would seem to be related to the mechanism of MV. Moreover, as the medical index of MV, peak frequency and amplitude for MD and LG were lower than that for the normal subjects. This tendency was emphasized by imposing increased load.
バイオメカニズム学会の論文
1984-04-25

筋ジストロフィー患者のマイクロバイブレーションに関する研究(1部ヒトのバイオメカニクス)

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筋ジストロフィー患者のマイクロバイブレーションに関する研究(1部 ヒトのバイオメカニクス)

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筋ジストロフィー患者のマイクロバイブレーションに関する研究(1部ヒトのバイオメカニクス)