コーヒー果実残渣による乳癌の予防・治療および泌乳促進に関する実験的研究 : Autobiographic minireview
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概要
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Coffee is one of the most popular beverages in many countries and approximately 5 million tons of its beans is consumed annually. The waste, called coffee cherry (CC), the residue left after the removal of coffee beans from the fruit, is also produced in a similar amount, and currently has only a few uses. Our research experience in the analysis of natural plants as components of Chinese herbal medicines inspired us to find an efficient use of CC, since some fruit portions may have medicinal significance. Thus, we have examined the effects of CC on the development and growth of spontaneous mammary tumours, lactation and some related parameters in SHN mice. Both development (Figure 1) and growth (Figure 2) of mammary tumours were markedly inhibited by chronic treatment with CC (0.5%) in drinking water. Associated with this, normal and preneoplastic growth of mammary glands were also suppressed (Figure 4). CC treatment resulted in a potentiation of immune functions such as an increase in the mature cells expressing helper/inducer or cytotoxic/suppresser phenotypes (Table 1), T cells expressing CD25, a lymphocyte activation marker, in the spleen and peripheral blood, CD45R/B220+(B) cells in the splenic lymphocytes and T-lymphocyte response to liposaccharide. CC treatment also modulated the blood and urine component levels bringing up the improvement of general metabolism. These suggest that CC-induced immuno- and metabolic-potentiation contributes to antitumourigenic roles of the agent. Lactational performance estimated by the pup growth was stimulated by CC (0.01% and 0.025%) (Figure 3); However, the treatment showed little effects on either the growth or function of mammary glands. Alternatively, the period in the nest of mother mice was elongated by CC (Figure 7) and, thus, the improvement by CC of the nesting behavior of mother mice was strongly suggested and it would result in the beneficial effects on pup growth. Any CC treatment modulated little the endocrine function; the pattern of oestrous cycles, ovarian weight and histology, serum levels of prolactin and growth hormone. Expecting the additive/ synergistic effects of CC and other agents with similar activity, simultaneous treatment with CC and hydroxiapatite (HAP) or whole-body hyperthermia (WBH), both having potent antitumour roles, were examined. The inhibitory effects of CC, HAP or WBH alone on the development and/ or growth of tumours were reduced by CC+HAP and CC+WBH (Table 2, Figure 8). Enhancement by CC or HAP of the excretion of urine components (Figure 5) was mostly nullified by CC+HAP. However, the decrease in body weight by CC or WBH alone was ameliorated by CC+HAP (Table 2) or CC+WBH (Figure 9). These findings confirmed the 'normalization' effects of CC usually observed in the natural products and stress the need for prudence in the choice of any agents to be applied simultaneously to increase the efficacy. Finally, CC is very promising as not only an antitumour agent but also more generally as a health maintenance element.
- 明治大学の論文
著者
関連論文
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- コーヒー果実残渣による乳癌の予防・治療および泌乳促進に関する実験的研究 : Autobiographic minireview
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