Effects of 2-(Hydroxyphenyl)indoles on the Formation of Preneoplastic Mammary Hyperplastic Alveolar Nodules and Uterine Adenomyosis in SHN Virgin Mice

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概要

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• Based on the information of the anticarcinogenicity of compounds 4a and 4b of 2-(hydroxyphenyl)indoles on carcinogen-induced rat mammary tumors, their effects on precancerous mammary hyperplastic alveolar nodules (HAN) and uterine adenomyosis in mice, which are under the control of hormones similar to rat mammary tumors, were studied. Both compounds showed a marked stimulation of HAN formation associated with the elevated prolactin in the circulation, the increased pituitary weight and the continued estrous vaginal smears at dose levels which inhibited the progression of rat mammary tumors. The results warrant the specific precaution to the choice of tumor types and/or animal species for checking hormone-related anticarcinogenicity of any agent. Either compound had no effects on the development of uterine adenomyosis, probably because of the quite declined response to the compounds of uterine cells of which mitotic activity was very low.

• 明治大学の論文

著者

• 二木 馨

  Department Of Biology School Of Education Waseda University:(present Address)deartment Of Entology A

• 並木 秀男

  Department Of Biology School Of Education Waseda University

• 長澤 弘

  Animal Breeding And Experimental Animal Research Laboratory Meiji University

• 野崎 大典

  Animal Breeding and Experimental Animal Research Laboratory, School of Agriculture, Meiji University

• 野崎 大典

  Animal Breeding And Experimental Animal Research Laboratory School Of Agriculture Meiji University:(

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