Mechanism on the Role of Prolactin in Erperimental Mammary Tumorigenesis: A Review
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1. Prolactin is a primary hormone for experimental mammary tumorigenesis. 2. One role of prolactin in the development of mammary tumors is to create mammary gland conditions favorable for the action of carcinogenic agents through its stimulation of frequency of normal epithelial cell division. 3. Prolactin acts as a promoter on the progression of tumors by directly stimulating the tumor cell division. Even spontaneous mammary tumors in mice, which are generally considered to be hormone-independent and autonomous in progression, are responsive to prolactin at the initial stage of progression. 4. Normal and neoplastic mammary gland cell susceptibility to prolactin is more important in mammary tumorigenesis than the circulating levels of the hormone. Meanwhile, plasma membrane prolactin receptor is not always a good indicator for the responsiveness of the cells to prolactin under normal physiological conditions. 5. Prolactin effects are modified by estrogen, which stimulates pituitary prolactin secretion on the one hand, and modulates mammary cell responsiveness to prolactin on the other.
- 明治大学の論文
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