Studies on Post-Transplant Dyslipidemia in Kidney Transplant Patients
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概要
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This study was performed to retrospectively compare changes in the levels of total cholesterol, non-HDL cholesterol, triglycerides, and immunosuppressive drugs, cyclosporine A and steroids in patients with living-relation renal transplants with those from non-heart-beating donors. We experienced 11 cases of kidney transplants from non-heart-beating donors during the period from April 1995 to May 2003. We evaluated 13 cases of kidney transplants from living-relation donors during the same period. The immunosuppressants used included mainly cyclosporine A as well as mycophenolate mofetil or azathioprine, steroid and ALG, or basiliximab. Over-night fasting lipids (total cholesterol, triglycerides and HDL cholesterol) were studied before renal transplantation and repeated after renal transplantation at 1, 3, 6 and 12 months. The levels of total cholesterol and triglycerides remained in the normal range before transplantation. However, the levels of total cholesterol increased siginificantly 1 and 3 months after transplantation from non-heart-beating donors and remained at higher levels up to 12 months after transplantation. A similar pattern in the levels of triglycerides was observed. The levels of HDL cholesterol remained unchanged and stayed in the normal range before and 1, 3, 6, and 12 months after transplantation from non-heart-beating donors. On the other hand, significant increases in non-HDL cholesterol were observed 3 and 6 months after transplantation from non-heart-beating donors. After transplantation from living-relation donors, levels of total cholesterol, triglycerides, and non-HDL cholesterol remained unchanged and remained in the normal range up to 12 months after transplantation. Although there were no significant differences in the total dosage of cyclosporine A between the patients with living-relation donors and those with non-heart-beating donors, a significant increase in the total dosage of methylprednisolone was observed in patients with non-heart-beating donors compared with those in the p
- 広島大学の論文
著者
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Fukuda Yasuhiko
Second Department Of Surgery Faculty Of Medicine Hiroshima University
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TASHIRO Hirotaka
Department of Gastroenterological Surgery, Hiroshima University Hospital
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ASAHARA Toshimasa
Department of Gastroenterological Surgery, Hiroshima University Hospital
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OHDAN Hideki
Department of Gastroenterological Surgery, Hiroshima University Hospital
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Ohdan Hideki
Department Of Gastroenterological Surgery Hiroshima University Hospital
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MARUBAYASHI SEIJI
Department of Blood Purification, Division of Frontier Medical Science, Programs for Biomedical Rese
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HAYAMIZU KEISUKE
Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University
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FUKUDA YASUHIKO
Department of Surgery, Hiroshima Prefectural Hospital
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TOKITA Daisuke
Department Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate
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ONOE Takashi
Department Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate
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DOI Shigehiro
Department of Blood Purification, Hiroshima University Hospital
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OKUMOTO Satoshi
Department of Blood Purification, Hiroshima University Hospital
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TANJI Chie
Department of Blood Purification, Hiroshima University Hospital
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KAWAI Tohru
Department of Blood Purification, Hiroshima University Hospital
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TANIGUCHI Yoshihiko
Department of Blood Purification, Hiroshima University Hospital
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DOHI Kiyohiko
Chugoku Rousai Hospital
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Tanji Chie
Department Of Blood Purification Hiroshima University Hospital
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Onoe Takashi
Department Surgery Division Of Frontier Medical Science Programs For Biomedical Research Graduate Sc
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Doi Shigehiro
Department Of Blood Purification Hiroshima University Hospital
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Tokita Daisuke
Department Surgery Division Of Frontier Medical Science Programs For Biomedical Research Graduate Sc
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Tokita Daisuke
Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University
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Okumoto Satoshi
Department Of Blood Purification Hiroshima University Hospital
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Tashiro Hirotaka
Department Of Gastroenterological Surgery Hiroshima University Hospital
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Tashiro Hirotaka
Department Of Chugoku Rosai Hospital Pharmacy Surgery Medical Technology
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Hayamizu Keisuke
Department Surgery Division Of Frontier Medical Science Programs For Biomedical Research Graduate Sc
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Asahara Toshimasa
Department Of Gastroenterological Surgery Hiroshima University Hospital
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Kawai Tohru
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Kawai Tohru
Department Of Blood Purification Hiroshima University Hospital
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Dohi K
Chugoku Rousai Hospital
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Marubayashi Seiji
Department Of Blood Purification Hiroshima University Hospital
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Taniguchi Yoshihiko
Department Of Surgery Division Of Frontier Medical Science Programs For Biomedical Research Graduate
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Asahara Toshimasa
Department Of Surgery Division Of Frontier Medical Science Programs For Biomedical Research Graduate
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ONOE Takashi
Department of Gastroenterological Surgery, Hiroshima University Hospital
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