Motility of the Canine Pyloric Ring Following a Pylorus-Preserving Pancreatoduodenectomy

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Recently, function-preserving operations have become popular, and pylorus-preserving pancreatoduodenectomy(PPPD)is frequently performed for diseases of the head of the pancreas. However, there are only a few basic studies on the pyloric function after PPPD. Using strain gauge force transducers(SGTs), we studied the pyloric motility of normal and PPPD dogs. We prepared three normal and three PPPD dogs in which the SGTs were implanted onto the antrum and pyloric ring, etc. In conscious dogs, the spontaneous gastrointestinal motility was recorded, and the plasma motilin concentration was measured during the interdigestive state. Following the administration of exogenous Leu^<13>-motilin, the motility was again recorded. The relaxation and opening of the pyloric ring was observed synchronously with intense contractions of the antrum during the phase III of normal dogs. Phase III-like motility was recorded in the PPPD dogs, which was not a typical periodic motility. The plasma motilin concentration of one PPPD dog could be measured, and the motilin levels during the phase III-like motility were higher than during phase I. The phase III-like motility was induced by Leu^<13>-motilin in both normal and PPPD dogs. The phase III-like motility recorded in the PPPD dogs was not a typical periodic one, and this aberrant motility was considered to be one of the causes of delayed gastric emptying. Phase III-like motility was induced by the administration of Leu^<13>-motilin;therefore, it is possible that Leu^<13>-motilin improved the motility of the pyloric ring after PPPD.
日本平滑筋学会の論文

Motility of the Canine Pyloric Ring Following a Pylorus-Preserving Pancreatoduodenectomy

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