早期動脈硬化症における,インスリン様成長因子 (IGF-1) とインスリン様成長因子結合蛋白-3 (IGFBP-3) の役割

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Objective-Growth hormone (GH) -insulin-like growth factor-1 (IGF-1) axis regulates growth and survival of vascular cells and cardiomyocytes. The role of GH-IGF-1 axis in cardiovascular disease is controversial. Methods and Results-We assessed the association of circulating levels of IGF-1 and IGF binding protein-3 (IGFBP-3) with early carotid atherosclerosis and atherosclerotic risk factors in 330 Japanese men (age 51.6±8.6 yr, range 29-77, body mass index 23.6±2.9 kg/m^2). Intima-media thickness (IMT) of the common carotid artery was measured by ultrasound. Abdominal visceral (VAT) and subcutaneous adipose tissue area by CT scan were determined. Correlation coefficients were calculated by Pearson's correlation test. Body mass index and plasma insulin showed positive associations with circulating IGF-1 and IGFBP-3. HDL-cholesterol was inversely associated with IGF-1. Blood pressure, total cholesterol, triglyceride and VAT were positively associated with IGFBP-3. IGF-1 and IGFBP-3 were associated with carotid IMT independent of age, smoking, body adiposity, blood pressure and insulin. Insulin was associated with carotid IMT in univariate analysis. However, it was not correlated with carotid IMT in the multivariate analyses which included IGF-1 as a covariate. Conclusion-Increased circulating IGF-1 and IGFBP-3 may be stimulators of atherosclerosis.
岐阜大学の論文
2003-03-31

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