内因性アンドロゲンと総頸動脈内膜中膜肥厚の関連について

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Background. The role of endogenous androgens in cardiovascular disease is controversial. Methods and Results. We examined the association of total testosterone (TT), bioavailable testosterone (BAT) and dehydroepiandrosterone sulfate (DHEAS) with early carotid atherosclerosis and cardiovascular risk factors. The study subjects were 400 healthy men with a mean age and body mass index (BMI) of 50.6±8.2 (SD) yr and 23.3±2.9 kg/m^2 respectively. Serum lipids, glucose, insulin, total testosterone, SHBG and DHEAS were measured. An index of insulin resistance derived from the homeostasis model (HOMA-R) was used. Percent body fat by a bioimpedance analysis and abdominal subcutaneous (ASF) and intraabdominal fat (IAF) area by CT scan were determined. Intimal-medial thickness (IMT) of the common carotid artery was measured by B-mode ultrasound. Correlation coefficients were calculated by Spearman's rank correlation. There was a positive association between carotid IMT and BAT levels. DHEAS was not associated with carotid IMT. BMI, % body fat and ASF, but not IAF, were positively correlated with DHEAS levels. All of these fat measures were inversely correlated with TT and BAT levels. Fasting plasma glucose, insulin and HOMA-R, were inversely correlated with TT levels. Fasting plasma insulin and HOMA-R, but not fasting plasma glucose, were inversely correlated with BAT levels. HDL-cholesterol showed a positive correlation with TT and BAT levels. None of these metabolic variables except for HDL-cholesterol were correlated with DHEAS. Conclusions. Testosterone showed favorable associations with cardiovascular risk factors in men. However, it was positively correlated with carotid intimal-medial thickness, an established marker of early atherosclerosis. Anti-atherosclerotic and anti-obesity effects of DHEAS were not supported.
岐阜大学の論文
2003-03-31

内因性アンドロゲンと総頸動脈内膜中膜肥厚の関連について

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